Pelegano J F, Rowe J C, Carey D E, LaBarre D J, Raye J R, Edgren K W, Horak E
Department of Pediatrics, University of Connecticut Health Center, Farmington 06032.
J Pediatr. 1989 Jan;114(1):115-9. doi: 10.1016/s0022-3476(89)80617-1.
We hypothesized that parenteral delivery of calcium and phosphorus in a ratio of 1.7:1 would promote retention of these minerals and decrease urinary phosphorus excretion, and that delivery of increased amounts of this ratio would result in higher retentions. Serum levels and retention of calcium and phosphorus were measured as calcium intake was increased from 36 to 76 mg/kg/day in 10 mg increments and as phosphorus intake was adjusted to maintain the 1.7:1 ratio. Five different infants were studied at each of the five levels. The amounts of calcium and phosphorus retained increased steadily and at level 5 were 71.8 +/- 1.2 mg/kg/day and 40.9 +/- 1.7 mg/kg/day, respectively. Over the five levels the average percent calcium retention was 91.4 +/- 4.2 and the average percent phosphorus retention was 89.1 +/- 7.7. The provision of parenteral calcium and phosphorus in a 1.7:1 ratio resulted in a balanced retention of both minerals over the range studied. The use of this calcium/phosphorus ratio appears to be appropriate for the preterm infant receiving total parenteral nutrition.
我们推测，以1.7:1的比例肠胃外输送钙和磷会促进这些矿物质的潴留，并减少尿磷排泄，且增加该比例的输送量会导致更高的潴留率。随着钙摄入量以10毫克的增量从36毫克/千克/天增加到76毫克/千克/天，且磷摄入量进行调整以维持1.7:1的比例，对钙和磷的血清水平及潴留情况进行了测量。在五个水平中的每个水平对五名不同的婴儿进行了研究。钙和磷的潴留量稳步增加，在第5水平时分别为71.8±1.2毫克/千克/天和40.9±1.7毫克/千克/天。在这五个水平上，钙的平均潴留百分比为91.4±4.2，磷的平均潴留百分比为89.1±7.7。以1.7:1的比例肠胃外输送钙和磷，在所研究的范围内导致了两种矿物质的平衡潴留。这种钙/磷比例的使用似乎适用于接受全肠胃外营养的早产儿。
