Bhagavath Bala, Vitek Wendy, Queenan John, Hoeger Kathleen
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Rochester Medical Center, Rochester, New York.
Semin Reprod Med. 2014 Jul;32(4):323-30. doi: 10.1055/s-0034-1375186. Epub 2014 Jun 11.
Polycystic ovary syndrome (PCOS) is a complex disorder affecting a substantial group of women from adolescent to menopausal age groups. A substantial subgroup of these women exhibits increased insulin resistance. Insulin resistance is difficult to establish in clinical practice and many surrogate tests are available, although their value in the clinical setting is uncertain. The QUICKI method is an inexpensive and easy test to administer and is probably the best test to be used in PCOS patients, preferably in a clinical trial context. There is considerable evidence that insulin-sensitizing agents are not contributory to infertility management in the majority of women with PCOS. Currently, there is no evidence that cardiovascular morbidity is decreased by long-term use of insulin sensitizers in PCOS women.
多囊卵巢综合征（PCOS）是一种复杂的疾病，影响着从青春期到绝经年龄组的大量女性。这些女性中的一个重要亚组表现出胰岛素抵抗增加。胰岛素抵抗在临床实践中难以确定，并且有许多替代检测方法，尽管它们在临床环境中的价值尚不确定。QUICKI方法是一种廉价且易于实施的检测方法，可能是用于PCOS患者的最佳检测方法，最好是在临床试验背景下。有大量证据表明，胰岛素增敏剂对大多数PCOS女性的不孕症管理并无帮助。目前，没有证据表明长期使用胰岛素增敏剂可降低PCOS女性的心血管发病率。
