Kodiakov D S, Klimachëv V V, Avdalian A M, Bobrov I P, Lazarev A F, Lushnikova E L, Nepomiashchikh L M
Vopr Onkol. 2014;60(2):63-8.
Investigated topoisomerase IIalpha (TopoII alpha), argyrophilic proteins associated with nucleolar organizer regions (Ag-NOR) and antigen Ki-67 in lung adenocarcinoma. Defined tumor with low and high TopoII alpha, Ag-NOR and Ki-67. TopoII alpha had a relationship with clinical and morphological parameters (greatest dimension, tumor differentiation) and proliferation markers (Ag-NOR, Ki-67) . Survival of patients with lung adenocarcinoma with low content of TopoII alpha is better as compared with high content of TopoII alpha. Survival of patients with lung adenocarcinoma depends on the mutual content of TopoII alpha and clinical and morphological parameters (value T, greatest dimension, value N, stage, tumor differentiation), proliferation markers (Ag-NOR). TopoII alpha content in lung adenocarcinoma is an independent prognostic factor. Mutual research of TopoII alpha with clinical and morphological parameters and Ag-NOR has prognostic value in lung adenocarcinoma.
研究了肺腺癌中的拓扑异构酶IIα（TopoIIα）、与核仁组织区相关的嗜银蛋白（Ag-NOR）和抗原Ki-67。定义了TopoIIα、Ag-NOR和Ki-67含量低和高的肿瘤。TopoIIα与临床和形态学参数（最大直径、肿瘤分化）以及增殖标志物（Ag-NOR、Ki-67）有关。TopoIIα含量低的肺腺癌患者的生存率高于TopoIIα含量高的患者。肺腺癌患者的生存率取决于TopoIIα与临床和形态学参数（T值、最大直径、N值、分期、肿瘤分化）、增殖标志物（Ag-NOR）的相互含量。肺腺癌中TopoIIα的含量是一个独立的预后因素。TopoIIα与临床和形态学参数以及Ag-NOR的相互研究在肺腺癌中具有预后价值。
