Malinova M
Akush Ginekol (Sofiia). 2014;53(1):40-3.
Pre-eclampsia and intrauterine growth restriction (IUGR) are responsible for approximately 15-20% of serious maternal and neonatal diseases. These complications are related to very early anomalies of the uteroplacental circulation, accompanied, at least secondarily, by thromboxane-prostacyclin-related imbalances. Studies have failed to show a beneficial effect of betamimetics and calcium channel blockers for the treatment of IUGR. Sildenafil citrate, a type 5-specific phosphodiesterase inhibitor, augments the vasodilatory effects of NO by preventing the degradation of cGMP There is a selective effect of Sildenafil on the uteroplacental circulation. Sildenafil improves uterine artery blood flow.
子痫前期和胎儿生长受限（IUGR）约占严重孕产妇和新生儿疾病的15%-20%。这些并发症与子宫胎盘循环的极早期异常有关，至少在继发时伴有血栓素-前列环素相关的失衡。研究未能显示β-拟交感神经药和钙通道阻滞剂对治疗IUGR有有益作用。枸橼酸西地那非是一种5型特异性磷酸二酯酶抑制剂，通过防止环磷酸鸟苷（cGMP）降解增强一氧化氮（NO）的血管舒张作用。西地那非对子宫胎盘循环有选择性作用。西地那非可改善子宫动脉血流。
