Maus Marcela V, June Carl H
Translational Research Program, Abramson Cancer Center; Departments of Medicine and.
Translational Research Program, Abramson Cancer Center; Pathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
Clin Cancer Res. 2014 Aug 1;20(15):3899-901. doi: 10.1158/1078-0432.CCR-14-0721. Epub 2014 Jun 11.
Chimeric antigen receptors redirect T cells to surface antigens. Discovery and validation of appropriate target antigens expands the possible indications for chimeric-antigen receptor (CAR) T cells. CS1 is expressed at high levels by multiple myeloma cells, but also to some extent on other lymphocytes. CS1 may be a viable target for CAR T cells in multiple myeloma.
嵌合抗原受体可将T细胞重定向至表面抗原。合适靶抗原的发现与验证拓展了嵌合抗原受体（CAR）T细胞的可能适应症。CS1在多发性骨髓瘤细胞中高水平表达，但在其他淋巴细胞上也有一定程度的表达。CS1可能是多发性骨髓瘤中CAR T细胞的一个可行靶点。
