Lucas C D, Amft N, Reid P T
Department of Respiratory Medicine, University of Edinburgh, Edinburgh EH16 4TJ, UK,
Department of Rheumatology, Western General Hospital, Edinburgh EH4 2XU, UK.
Occup Med (Lond). 2014 Jul;64(5):387-90. doi: 10.1093/occmed/kqu060. Epub 2014 Jun 10.
Inhalation of crystalline silica is known to result in silicosis: an irreversible, disabling and potentially fatal occupational lung disease, which is associated with a variety of pulmonary and non-pulmonary complications including autoimmunity. A potential link between silicosis and systemic lupus erythematosus (SLE) is currently recognized only in cases of acute or accelerated silicosis. We report a case of SLE, a disease which usually affects young females, arising in a male former stonemason with simple silicosis. Epidemiological and clinical literature on the association of silica exposure and development of SLE are briefly reviewed. This case report and literature review highlight the link between occupational silica exposure and autoimmune disease including SLE, establishes that even simple silicosis appears linked to development of autoimmunity and emphasizes the importance of an occupational history, especially in male patients who develop SLE.
一种不可逆转、使人致残且可能致命的职业性肺病，它与包括自身免疫在内的多种肺部和非肺部并发症相关。目前，矽肺病与系统性红斑狼疮（SLE）之间的潜在联系仅在急性或加速性矽肺病病例中得到认可。我们报告了一例SLE病例，该病通常影响年轻女性，而此病例发生在一名患有单纯矽肺病的男性前石匠身上。本文简要回顾了关于二氧化硅暴露与SLE发病之间关联的流行病学和临床文献。该病例报告和文献回顾突出了职业性二氧化硅暴露与包括SLE在内的自身免疫性疾病之间的联系，证实即使是单纯矽肺病似乎也与自身免疫的发展有关，并强调了职业病史的重要性，尤其是在患SLE的男性患者中。
