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矽肺与皮肌炎的关联:病例报告及文献综述

Association of Silicosis and Dermatomyositis: Case Report and Literature Review.

作者信息

Chanbour Hani, Jiblawi Ahmad, Aboudalle Ahmad, Alalman Obada, Chahine Elsett Zahia

机构信息

Neurosurgery, Lebanese University Faculty of Medicine, Beirut, LBN.

Radiology, American University of Beirut Medical Center, Beirut, LBN.

出版信息

Cureus. 2021 Nov 24;13(11):e19875. doi: 10.7759/cureus.19875. eCollection 2021 Nov.

DOI:10.7759/cureus.19875
PMID:34976496
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8712211/
Abstract

The association between silicosis and autoimmune diseases is not uncommon. Silicosis is well correlated with rheumatoid arthritis and systemic lupus erythematosus. However, cases of dermatomyositis associated with silicosis are relatively understudied. We report a case of a 59-year-old man with a history of cardiac, respiratory, and systemic symptoms for the duration of a year, who present to the ER with acute dyspnea, fever, chest pain, and dry cough, and was diagnosed with silicosis and dermatomyositis. In this case report, we discuss the workup done in order to reach the diagnosis, as well as the pathological mechanism that might have led to the emergence of those two entities in the same patient.

摘要

矽肺与自身免疫性疾病之间的关联并不罕见。矽肺与类风湿性关节炎和系统性红斑狼疮密切相关。然而,与矽肺相关的皮肌炎病例相对研究较少。我们报告一例59岁男性,有心脏、呼吸和全身症状长达一年,因急性呼吸困难、发热、胸痛和干咳就诊于急诊室,被诊断为矽肺和皮肌炎。在本病例报告中,我们讨论了为明确诊断所做的检查,以及可能导致同一患者出现这两种疾病的病理机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd3e/8712211/f7f9383543b3/cureus-0013-00000019875-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd3e/8712211/e90df46e75ba/cureus-0013-00000019875-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd3e/8712211/e6862210b540/cureus-0013-00000019875-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd3e/8712211/4e0239de0127/cureus-0013-00000019875-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd3e/8712211/f7f9383543b3/cureus-0013-00000019875-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd3e/8712211/e90df46e75ba/cureus-0013-00000019875-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd3e/8712211/e6862210b540/cureus-0013-00000019875-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd3e/8712211/4e0239de0127/cureus-0013-00000019875-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd3e/8712211/f7f9383543b3/cureus-0013-00000019875-i04.jpg

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本文引用的文献

1
Crystalline Silica Impairs Efferocytosis Abilities of Human and Mouse Macrophages: Implication for Silica-Associated Systemic Sclerosis.结晶二氧化硅削弱人源和鼠源巨噬细胞的噬作用能力:对与二氧化硅相关的系统性硬皮病的影响。
Front Immunol. 2020 Feb 18;11:219. doi: 10.3389/fimmu.2020.00219. eCollection 2020.
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Occup Environ Med. 2019 Feb;76(2):134. doi: 10.1136/oemed-2018-105563. Epub 2018 Dec 11.
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[Fas-Fas ligand system in silicosis patients].矽肺患者的Fas-Fas配体系统
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