Bakolis I, Heinrich J, Zock J P, Norbäck D, Svanes C, Chen C M, Accordini S, Verlato G, Olivieri M, Jarvis D
Small Area Health Statistics Unit, MRC-HPA Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Indoor Air. 2015 Jun;25(3):235-44. doi: 10.1111/ina.12137. Epub 2014 Jul 7.
Exposure to house dust has been associated with asthma in adults, and this is commonly interpreted as a direct immunologic response to dust-mite allergens in those who are IgE sensitized to house dust-mite. Mattress house dust-mite concentrations were measured in a population-based sample of 2890 adults aged between 27 and 56 years living in 22 centers in 10 countries. Generalized linear mixed models were employed to explore the association of respiratory symptoms with house dust-mite concentrations, adjusting for individual and household confounders. There was no overall association of respiratory outcomes with measured house dust-mite concentrations, even in those who reported they had symptoms on exposure to dust and those who had physician-diagnosed asthma. However, there was a positive association of high serum specific IgE levels to HDM (>3.5 kUA /l) with mattress house dust-mite concentrations and a negative association of sensitization to cat with increasing house dust-mite concentrations. In conclusion, there was no evidence that respiratory symptoms in adults were associated with exposure to house dust-mite allergen in the mattress, but an association of house mite with strong sensitization was observed.
接触室内灰尘与成人哮喘有关，这通常被解释为对屋尘螨IgE致敏的人对尘螨过敏原的直接免疫反应。在10个国家22个中心的2890名年龄在27至56岁之间的成年人的基于人群的样本中，测量了床垫上的屋尘螨浓度。采用广义线性混合模型探讨呼吸道症状与屋尘螨浓度之间的关联，并对个体和家庭混杂因素进行了调整。即使在那些报告接触灰尘时有症状的人和那些经医生诊断患有哮喘的人中，呼吸道结局与所测量的屋尘螨浓度之间也没有总体关联。然而，血清特异性IgE水平升高至HDM（>3.5 kUA /l）与床垫屋尘螨浓度呈正相关，而对猫的致敏与屋尘螨浓度增加呈负相关。总之，没有证据表明成人的呼吸道症状与接触床垫中的屋尘螨过敏原有关，但观察到屋螨与强致敏之间存在关联。
