Furuhata Masanori, Aihara Yasuo, Eguchi Seiichiro, Horiba Ayako, Tanaka Masahiko, Komori Takashi, Okada Yoshikazu
Department of Neurosurgery, Tokyo Women's Medical University Hospital.
No Shinkei Geka. 2014 Jun;42(6):545-51.
Medulloblastomas usually cause cerebellar ataxia and acute hydrocephalus owing to their increase in size. Cerebellar hemorrhage is an extremely rare initial clinical presentation of medulloblastoma. Herein, we report a case of medulloblastoma in an 8-year-old girl who presented with initial cerebellar intratumoral hemorrhage. The patient initially presented with mild headache;the differential diagnosis by using the initial computed tomography and magnetic resonance images was difficult, as bleeding from a cerebellar vascular malformation(cavernous angioma or arteriovenous malformation)was considered more likely. Hydrocephalus or typical findings indicative of medulloblastoma were not observed. We initially only observed the patient at another institution because the hematoma was relatively small(1.5×1×1cm). After follow-up imaging for pathological diagnosis, surgical removal was performed at our institute 49 days after the hemorrhage was observed. Complete tumor removal was achieved, and the histopathological diagnosis was medulloblastoma. The patient received whole brain and spinal irradiation(23.4Gy;posterior fossa local:50.4Gy)and chemotherapy(cyclophosphamide, 1,000mg/m2/day on day 1;vincristine, 1.5mg/m2/day on day 1;etoposide, 100mg/m2/day on days 1-3;cisplatin, 90mg/m2/day on day 2). No recurrences or neurological deficits were observed during a 2-year follow-up. This was a rare case of medulloblastoma presenting as cerebellar hemorrhage. Cerebellar medulloblastoma is among the common pediatric brain tumors;therefore, it should be diagnosed accurately and quickly.
髓母细胞瘤通常因其体积增大而导致小脑共济失调和急性脑积水。小脑出血是髓母细胞瘤极为罕见的初始临床表现。在此,我们报告一例8岁女孩的髓母细胞瘤病例,其最初表现为小脑肿瘤内出血。患者最初表现为轻度头痛;使用初始计算机断层扫描和磁共振图像进行鉴别诊断较为困难,因为小脑血管畸形(海绵状血管瘤或动静脉畸形)出血被认为更有可能。未观察到脑积水或提示髓母细胞瘤的典型表现。由于血肿相对较小(1.5×1×1cm),我们最初仅在另一家机构对患者进行观察。在进行病理诊断的后续影像学检查后,在观察到出血49天后于我院进行了手术切除。实现了肿瘤的完全切除,组织病理学诊断为髓母细胞瘤。患者接受了全脑和脊髓照射(23.4Gy;后颅窝局部:50.4Gy)以及化疗(环磷酰胺,第1天1000mg/m²/天;长春新碱,第1天1.5mg/m²/天;依托泊苷,第1 - 3天100mg/m²/天;顺铂,第2天90mg/m²/天)。在2年的随访期间未观察到复发或神经功能缺损。这是一例罕见的以小脑出血为表现的髓母细胞瘤病例。小脑髓母细胞瘤是常见的儿童脑肿瘤之一;因此,应准确、快速地进行诊断。