Jamie P. Morano, Alexei Zelenev, Mary R. Walton, R. Douglas Bruce, and Frederick L. Altice are with the Yale School of Medicine, Department of Infectious Diseases, Yale University AIDS Program, New Haven, CT. R. D. Bruce and F. L. Altice are also affiliated with the Yale School of Public Health, Division of Epidemiology of Microbial Diseases, New Haven. F. L. Altice is also associated with the Centre of Excellence in Research in AIDS, University of Malaya, Kuala Lumpur, Malaysia.
Am J Public Health. 2014 Aug;104(8):1508-15. doi: 10.2105/AJPH.2014.301897. Epub 2014 Jun 12.
We evaluated the efficacy of a mobile medical clinic (MMC) screening program for detecting latent tuberculosis infection (LTBI) and active tuberculosis.
A LTBI screening program in a MMC in New Haven, Connecticut, used medical surveys to examine risk factors and tuberculin skin test (TST) screening eligibility. We assessed clinically relevant correlates of total (prevalent; n = 4650) and newly diagnosed (incident; n = 4159) LTBI from 2003 to 2011.
Among 8322 individuals, 4159 (55.6%) met TST screening eligibility criteria, of which 1325 (31.9%) had TST assessed. Similar to LTBI prevalence (16.8%; 779 of 4650), newly diagnosed LTBI (25.6%; 339 of 1325) was independently correlated with being foreign-born (adjusted odds ratio [AOR] = 8.49; 95% confidence interval [CI] = 5.54, 13.02), Hispanic (AOR = 3.12; 95% CI = 1.88, 5.20), Black (AOR = 2.16; 95% CI = 1.31, 3.55), employed (AOR = 1.61; 95% CI = 1.14, 2.28), and of increased age (AOR = 1.04; 95% CI = 1.02, 1.05). Unstable housing (AOR = 4.95; 95% CI = 3.43, 7.14) and marijuana use (AOR = 1.57; 95% CI = 1.05, 2.37) were significantly correlated with incident LTBI, and being male, heroin use, interpersonal violence, employment, not having health insurance, and not completing high school were significantly correlated with prevalent LTBI.
Screening for TST in MMCs successfully identifies high-risk foreign-born, Hispanic, working, and uninsured populations and innovatively identifies LTBI in urban settings.
评估移动医疗诊所(MMC)筛查项目在检测潜伏性结核感染(LTBI)和活动性肺结核方面的效果。
在康涅狄格州纽黑文市的 MMC 中开展 LTBI 筛查项目,采用医疗问卷调查来检测风险因素和结核菌素皮肤试验(TST)筛查的资格。我们评估了 2003 年至 2011 年期间总(流行;n=4650)和新诊断(发病;n=4159)LTBI 的临床相关相关性。
在 8322 名个体中,有 4159 名(55.6%)符合 TST 筛查资格标准,其中有 1325 名(31.9%)接受了 TST 评估。与 LTBI 患病率(16.8%;4650 名中的 779 名)相似,新发 LTBI(25.6%;1325 名中的 339 名)与出生在国外(调整后的优势比 [AOR]为 8.49;95%置信区间 [CI]为 5.54,13.02)、西班牙裔(AOR 为 3.12;95%CI 为 1.88,5.20)、黑人(AOR 为 2.16;95%CI 为 1.31,3.55)、就业(AOR 为 1.61;95%CI 为 1.14,2.28)和年龄增长(AOR 为 1.04;95%CI 为 1.02,1.05)有关。不稳定的住房(AOR 为 4.95;95%CI 为 3.43,7.14)和大麻使用(AOR 为 1.57;95%CI 为 1.05,2.37)与发病 LTBI 显著相关,而男性、海洛因使用、人际暴力、就业、没有医疗保险和没有完成高中学业与流行 LTBI 显著相关。
在 MMC 中筛查 TST 可成功识别高危的出生在国外、西班牙裔、工作和没有医疗保险的人群,并创新性地在城市环境中发现 LTBI。