1991年至2010年西澳大利亚州1型糖尿病发病率的时空变化：高纬度地区及随时间推移风险增加。
Spatial and temporal variation in type 1 diabetes incidence in Western Australia from 1991 to 2010: increased risk at higher latitudes and over time.
作者信息
Ball Stephen J, Haynes Aveni, Jacoby Peter, Pereira Gavin, Miller Laura J, Bower Carol, Davis Elizabeth A
机构信息
Telethon Kids Institute, The University of Western Australia, 100 Roberts Road, Subiaco, WA 6008, Australia.
Telethon Kids Institute, The University of Western Australia, 100 Roberts Road, Subiaco, WA 6008, Australia; Department of Endocrinology and Diabetes, Princess Margaret Hospital, Roberts Road, Subiaco, WA 6008, Australia.
出版信息
Health Place. 2014 Jul;28:194-204. doi: 10.1016/j.healthplace.2014.05.004. Epub 2014 Jun 10.
This study analysed spatial and temporal variation in childhood incidence of type 1 diabetes mellitus (T1DM) among Western Australia׳s 36 Health Districts from 1991 to 2010. There was a strong latitudinal gradient of 3.5% (95% CI, 0.2-7.2) increased risk of T1DM per degree south of the Equator, as averaged across the range 15-35° south. This pattern is consistent with the hypothesis of vitamin D deficiency at higher latitudes. In addition there was a 2.4% (95% CI, 1.3-3.6) average increase in T1DM incidence per year. These effects could not be explained by population density, socioeconomic status, remoteness or ethnicity.
本研究分析了1991年至2010年西澳大利亚州36个卫生区1型糖尿病（T1DM）儿童发病率的时空变化。在南纬15°至35°范围内平均计算，赤道以南每度T1DM风险增加3.5%（95%可信区间，0.2 - 7.2），存在很强的纬度梯度。这种模式与高纬度地区维生素D缺乏的假设一致。此外，T1DM发病率每年平均增加2.4%（95%可信区间，1.3 - 3.6）。这些影响无法用人口密度、社会经济地位、偏远程度或种族来解释。
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