Ball Stephen J, Haynes Aveni, Jacoby Peter, Pereira Gavin, Miller Laura J, Bower Carol, Davis Elizabeth A
Telethon Kids Institute, The University of Western Australia, 100 Roberts Road, Subiaco, WA 6008, Australia.
Telethon Kids Institute, The University of Western Australia, 100 Roberts Road, Subiaco, WA 6008, Australia; Department of Endocrinology and Diabetes, Princess Margaret Hospital, Roberts Road, Subiaco, WA 6008, Australia.
Health Place. 2014 Jul;28:194-204. doi: 10.1016/j.healthplace.2014.05.004. Epub 2014 Jun 10.
This study analysed spatial and temporal variation in childhood incidence of type 1 diabetes mellitus (T1DM) among Western Australia׳s 36 Health Districts from 1991 to 2010. There was a strong latitudinal gradient of 3.5% (95% CI, 0.2-7.2) increased risk of T1DM per degree south of the Equator, as averaged across the range 15-35° south. This pattern is consistent with the hypothesis of vitamin D deficiency at higher latitudes. In addition there was a 2.4% (95% CI, 1.3-3.6) average increase in T1DM incidence per year. These effects could not be explained by population density, socioeconomic status, remoteness or ethnicity.
本研究分析了1991年至2010年西澳大利亚州36个卫生区1型糖尿病（T1DM）儿童发病率的时空变化。在南纬15°至35°范围内平均计算，赤道以南每度T1DM风险增加3.5%（95%可信区间，0.2 - 7.2），存在很强的纬度梯度。这种模式与高纬度地区维生素D缺乏的假设一致。此外，T1DM发病率每年平均增加2.4%（95%可信区间，1.3 - 3.6）。这些影响无法用人口密度、社会经济地位、偏远程度或种族来解释。
