生长抑素受体在正常膀胱组织和膀胱癌组织样本中的表达模式。
Pattern of somatostatin receptors expression in normal and bladder cancer tissue samples.
机构信息
Department of Physiology, Medical School, National & Kapodistian University of Athens, Athens, Greece.
Department of Physiology, Medical School, National & Kapodistian University of Athens, Athens, Greece Department of Internal Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, NY, U.S.A.
出版信息
Anticancer Res. 2014 Jun;34(6):2937-42.
BACKGROUND/AIM: Known risks factors for bladder cancer progression and recurrence are limited regarding their prognostic ability. Therefore identification of molecular determinants of disease progression could provide with more specific prognostic information and could be translated into new approaches for biomarker development. In the present study we evaluated, the expression patterns of somatostatin receptors 1-5 (SSTRs) in normal and tumor bladder tissues.
MATERIALS AND METHODS
The expression of SSTR1-5 was characterized in 45 normal and bladder cancer tissue samples using reverse transcriptase-polymerase chain reaction (RT-PCR).
RESULTS
SSTR1 was expressed in 24 samples, SSTR2 in 15, SSTR3 in 23, SSTR4 in 16 and SSTR5 in all but one sample. Bladder cancer tissue samples expressed lower levels of SSTR3. Co-expression of SSTRs was associated with superficial disease.
CONCLUSION
Our results demonstrate, for the first time, that there is expression of SSTR in normal and bladder cancer urothelium. Further studies are required to evaluate the prognostic and therapeutic significance of these findings.
背景/目的：关于膀胱癌进展和复发的已知风险因素，其预测能力有限。因此，确定疾病进展的分子决定因素可以提供更具特异性的预后信息，并可以转化为开发生物标志物的新方法。在本研究中，我们评估了生长抑素受体 1-5（SSTRs）在正常和肿瘤膀胱组织中的表达模式。
材料和方法
使用逆转录-聚合酶链反应（RT-PCR）对 45 个正常和膀胱癌组织样本中的 SSTR1-5 表达进行了表征。
结果
SSTR1 在 24 个样本中表达，SSTR2 在 15 个样本中表达，SSTR3 在 23 个样本中表达，SSTR4 在 16 个样本中表达，SSTR5 在所有样本中表达，除了一个样本。膀胱癌组织样本中 SSTR3 的表达水平较低。SSTRs 的共表达与表浅疾病相关。
结论
我们的研究结果首次表明，SSTR 在正常和膀胱癌尿路上皮中表达。需要进一步研究来评估这些发现的预后和治疗意义。
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