Wu En-Qi, Tang Yuan-Yu
Bing Du Xue Bao. 2014 Mar;30(2):201-7.
High-risk human papillomavirus (HPV) is the principal cause of various cancers including cervical cancer, anal cancer, vulvar cancer, and some head and neck cancers. In the viral life cycle, by interacting with both viral and host DNA and proteins, the HPV E2 protein plays a pivotal role in viral transcriptional regulation and DNA replication, and it is also associated with modification of various cellular processes, including host gene transcription, RNA processing, apoptosis, ubiquitination, and intracellular trafficking, to create a convenient environment for a replicative cycle of the virus and contribute to the HPV pathogenesis. Elucidating the roles of E2 protein throughout the viral life cycle will improve our understanding of the viral life cycle and pathogenesis and help us identify novel antiviral agents with therapeutic potential. This article reviews the research progress in the structure, roles, and activity of high-risk HPV E2 protein, particularly that of HPV-16.
高危型人乳头瘤病毒（HPV）是包括宫颈癌、肛门癌、外阴癌以及一些头颈癌在内的多种癌症的主要病因。在病毒生命周期中，HPV E2蛋白通过与病毒及宿主的DNA和蛋白质相互作用，在病毒转录调控和DNA复制中发挥关键作用，还与包括宿主基因转录、RNA加工、凋亡、泛素化及细胞内运输等多种细胞过程的调控相关，从而为病毒的复制周期创造有利环境并推动HPV致病进程。阐明E2蛋白在整个病毒生命周期中的作用将增进我们对病毒生命周期和致病机制的理解，并有助于我们鉴定具有治疗潜力的新型抗病毒药物。本文综述了高危型HPV E2蛋白，尤其是HPV-16 E2蛋白在结构、作用及活性方面的研究进展。
