May-Ling June Lee, Loxton Deborah, McLaughlin Deirdre
School of Population Health, The University of Queensland, Herston Road, Herston, QLD, 4006, Australia.
J Behav Med. 2015 Feb;38(1):57-65. doi: 10.1007/s10865-014-9577-2. Epub 2014 Jun 13.
The objective of the current study was to examine whether exposure to trauma in the form of a history of physical, mental, emotional or sexual abuse or violence predicted new onset of coronary heart disease (CHD) in women. In addition, this study aimed to examine the mediation effects of psychological, lifestyle and health related factors in the abuse-CHD relationship. Data from 6 surveys over 15 years, from the Australian Longitudinal Study on Women's Health, a large prospective cohort study, were used. Participants from the 1946-1951 cohort who did not self-report heart disease at surveys 1 (1996) and 2 (1998) and who had provided information on other variables were included (n = 9,276). After adjusting for age, women who reported trauma exposure at baseline were 1.54 times more likely (95% confidence interval 1.29-1.83) to report new onset of CHD than those who did not report trauma exposure. The association between trauma and CHD was largely explained by psychological factors, suggesting a direct pathway between exposure to trauma and risk of CHD.
本研究的目的是检验遭受身体、精神、情感或性虐待或暴力史形式的创伤是否能预测女性冠心病（CHD）的新发情况。此外，本研究旨在检验心理、生活方式和健康相关因素在虐待与冠心病关系中的中介作用。使用了来自澳大利亚女性健康纵向研究的15年间6次调查的数据，这是一项大型前瞻性队列研究。纳入了1946 - 1951队列中在第1次调查（1996年）和第2次调查（1998年）时未自我报告患有心脏病且提供了其他变量信息的参与者（n = 9276）。在调整年龄后，基线时报告有创伤暴露的女性报告冠心病新发的可能性是未报告创伤暴露女性的1.54倍（95%置信区间1.29 - 1.83）。创伤与冠心病之间的关联在很大程度上由心理因素解释，这表明创伤暴露与冠心病风险之间存在直接途径。
