Cazala P, Guenet J L
Laboratoire de Psychophysiologie, Université de Bordeaux I, Avenue des Facultés, 33405 Talence France.
Départment de Biologie Moléculaire, Institut Pasteur, 25 rue du Docteur Roux, 75015 Paris France.
Behav Processes. 1976 Jul;1(1):93-7. doi: 10.1016/0376-6357(76)90009-7.
Intracranial self-stimulation behaviour in the lateral hypothalamus was studied in male mice obtained from a backcross between the F1 generation BALB/c J × DBA/2 J and the strain BALB/c J, recessive for the majority of the self-stimulation parameters. The 48 animals of the backcross were divided into 3 groups at the 40 μ A intensity. One group of 11 mice had mean performances similar to those of the recessive parental strain BALB/c. This result suggests that the genetic determination of the difference of self-stimulation performances observed between BALB/c and DBA/2 strains is not very complex. A negative correlation appeared between the thresholds and the performances of self-stimulation. Finally, stimulation intensities above 40 μ A triggered convulsion with similar frequencies in the three backcross groups.
对通过F1代BALB/c J×DBA/2 J与BALB/c J品系回交得到的雄性小鼠进行了下丘脑外侧的颅内自我刺激行为研究，该品系在大多数自我刺激参数方面呈隐性。回交得到的48只动物在40微安强度下被分为3组。一组11只小鼠的平均表现与隐性亲本品系BALB/c相似。这一结果表明，BALB/c和DBA/2品系之间观察到的自我刺激表现差异的遗传决定并不十分复杂。自我刺激的阈值与表现之间呈现负相关。最后，在三个回交组中，高于40微安的刺激强度引发惊厥的频率相似。
