Bellone S, Esposito S, Giglione E, Genoni G, Fiorito C, Petri A, Bona G, Prodam F
Division of Pediatrics, Department of Health Sciences, University of Piemonte Orientale "Amedeo Avogadro", Via Solaroli 17, 28100, Novara, Italy.
J Endocrinol Invest. 2014 Sep;37(9):805-9. doi: 10.1007/s40618-014-0108-3. Epub 2014 Jun 13.
Vitamin D exerts pleiotropic effects and few studies are available in the Italian population.
Aim of our study was to evaluate vitamin D status in children living in Northern Italy.
We studied vitamin D levels in a population of 113 normal weight (NW) and 444 obese (OB) children, prepubertal and pubertal. We considered vitamin D levels >20 ng/ml as normal, but also measured percentage of children with vitamin D levels higher than a cutoff of 30 ng/ml.
68.2 % of NW children showed normal levels of vitamin D, while 31.8 % showed a clear vitamin D deficiency. Only 28.3 % showed vitamin D levels higher than 30 ng/ml. Obese children showed 55.6 % of subjects with normal levels of vitamin D and 44.4 % of subjects a status of vitamin D deficiency. Only the 18.9 % showed vitamin D levels higher than 30 ng/ml. Mean vitamin D levels in NW children (27.3 ± 1.2 ng/ml) were higher than in OB children (21.8 ± 0.6 ng/ml). No differences have been found between prepubertal and pubertal children in terms of vitamin D levels.
Our paediatric population demonstrates a low percentage of vitamin D sufficiency. In particular, obese children show only 19 % of subjects with normal levels while almost half of this population shows a clear deficiency. Further studies are needed to support these results and to evaluate the possible metabolic consequences.
维生素D具有多种效应，而针对意大利人群的相关研究较少。
我们研究的目的是评估意大利北部儿童的维生素D状况。
我们对113名正常体重（NW）儿童和444名肥胖（OB）儿童（青春期前和青春期）的维生素D水平进行了研究。我们将维生素D水平>20 ng/ml视为正常，同时还测量了维生素D水平高于30 ng/ml临界值的儿童百分比。
68.2%的NW儿童维生素D水平正常，而31.8%的儿童存在明显的维生素D缺乏。只有28.3%的儿童维生素D水平高于30 ng/ml。肥胖儿童中，55.6%的受试者维生素D水平正常，44.4%的受试者存在维生素D缺乏状态。只有18.9%的儿童维生素D水平高于30 ng/ml。NW儿童的平均维生素D水平（27.3±1.2 ng/ml）高于OB儿童（21.8±0.6 ng/ml）。青春期前和青春期儿童在维生素D水平方面未发现差异。
我们的儿科人群显示维生素D充足的比例较低。特别是，肥胖儿童中只有19%的受试者维生素D水平正常，而几乎一半的肥胖儿童存在明显缺乏。需要进一步研究来支持这些结果并评估可能的代谢后果。
