Department of Physiology, Faculty of Medicine, Semmelweis University, Budapest, H-1094, Hungary; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Department of Physiology, Faculty of Medicine, Semmelweis University, Budapest, H-1094, Hungary; "Lendület" Peroxidase Enzyme Research Group of the Semmelweis University and the Hungarian Academy of Sciences, Budapest, Hungary.
Trends Biochem Sci. 2014 Jul;39(7):305-7. doi: 10.1016/j.tibs.2014.05.005. Epub 2014 Jun 9.
Stabilization of extracellular matrix by protein crosslinking is a universal and essential process in multicellular organisms. Recent findings revealed that peroxidasin, a unique heme-peroxidase, produces hypohalides to support matrix synthesis. Unexpectedly, the highly reactive and potentially damaging hypohalides mediate the formation of sulfilimine bonds between adjacent collagen IV protomers. This crosslink is a fundamental feature of basal membranes, defining peroxidasin-dependent oxidant generation and sulfilimine crosslink formation as an elemental mechanism of tissue biogenesis.
细胞外基质的稳定由蛋白质交联来实现，这是多细胞生物中的一个普遍且必需的过程。最近的研究结果表明，过氧化物酶体，一种独特的血红素过氧化物酶，产生次卤酸盐来支持基质的合成。出人意料的是，高反应性和潜在破坏性的次卤酸盐介导相邻的 IV 型胶原原纤维之间的亚磺酰亚胺键的形成。这种交联是基底膜的一个基本特征，这表明过氧化物酶体依赖的氧化剂生成和亚磺酰亚胺交联的形成是组织发生的基本机制。
