1型神经纤维瘤病合并单侧视神经胶质瘤患儿的屈光参差

Anisometropia in children with neurofibromatosis type 1 and unilateral optic nerve glioma.

作者信息

Dotan Gad, Keren Shay, Stolovitch Chaim, Toledano-Alhadef Hagit, Kesler Anat

机构信息

Department of Ophthalmology, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; Maccabi Healthcare Services, Ramat Hsharon, Israel.

Department of Ophthalmology, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

出版信息

J AAPOS. 2014 Jun;18(3):255-7. doi: 10.1016/j.jaapos.2014.01.010.

DOI:10.1016/j.jaapos.2014.01.010

PMID:24924279

Abstract

BACKGROUND

Optic nerve glioma (ONG) occurs in 5% to 25% of individuals with neurofibromatosis type 1 (NF1). Recently an association between this lesion and unilateral myopia was reported in a series of 4 pediatric patients. The purpose of this study was to determine whether unilateral ONG is associated with an increased prevalence of anisometropia.

METHODS

The medical records of children <16 years of age with NF1 disease and unilateral ONG or normal neuroimaging examined at Tel-Aviv Medical Center between April 2008 and July 2013 were retrospectively reviewed to determine the prevalence of anisometropia and anisoastigmatism.

RESULTS

A total of 75 children with NF1 disease were included. Of these, 25 (11 boys) had a unilateral ONG (mean age, 7.2 years; range, 2-16 years) and 50 (29 boys) had normal neuroimaging (mean age, 8.3 years; range, 1-15 years). The mean refraction (spherical equivalent) of eyes with ONG did not differ significantly from that of the contralateral eyes (0.74 ± 1.41 D vs 0.71 ± 1.19 D; P = 0.935; 95% CI, -0.710 to 0.770); moreover, there was a high correlation between the refraction of eyes with ONG and contralateral eyes (r = 0.946, P < 0.001). The prevalence of anisometropia in children with ONG and in NF1 children with no orbital pathology did not differ significantly (8% vs 16%; P = 0.480), and the prevalence of anisoastigmatism was also similar in both groups (4% vs 14%, P = 0.255).

CONCLUSIONS

ONG in children with NF1 is not associated with increased prevalence of anisometropia.

摘要

背景

视神经胶质瘤（ONG）发生于5%至25%的1型神经纤维瘤病（NF1）患者中。最近，在一系列4例儿科患者中报道了这种病变与单侧近视之间的关联。本研究的目的是确定单侧ONG是否与屈光参差患病率增加有关。

方法

回顾性分析2008年4月至2013年7月在特拉维夫医疗中心检查的16岁以下患有NF1疾病且有单侧ONG或神经影像学正常的儿童的病历，以确定屈光参差和散光参差的患病率。

结果

共纳入75例NF1疾病患儿。其中，25例（11例男孩）患有单侧ONG（平均年龄7.2岁；范围2 - 16岁），50例（29例男孩）神经影像学正常（平均年龄8.3岁；范围1 - 15岁）。患有ONG的眼睛的平均屈光度（等效球镜）与对侧眼睛相比无显著差异（0.74±1.41 D对0.71±1.19 D；P = 0.935；95%CI，-0.710至0.770）；此外，患有ONG的眼睛与对侧眼睛的屈光度之间存在高度相关性（r = 0.946，P < 0.001）。患有ONG的儿童和无眼眶病变的NF1儿童中屈光参差的患病率无显著差异（8%对16%；P = 0.480），两组中散光参差的患病率也相似（4%对14%，P = 0.255）。