Phi Ji H, Goobie Susan M, Hong Ki H, Dholakia Ayesha, Smith Edward R
Division of Pediatric Neurosurgery, Seoul National University Children's Hospital, Seoul, Korea.
Paediatr Anaesth. 2014 Jul;24(7):791-3. doi: 10.1111/pan.12447.
Choroid plexus papilloma (CPP) is a highly vascular tumor of infancy. Reducing blood loss is the key to successful surgical removal of CPPs. Tranexamic acid (TXA) is efficacious in reducing bleeding in craniofacial surgery for infants. This report demonstrates the potential utility of TXA for decreasing blood loss in the removal of vascular tumors in infants. We administered tranexamic acid to two infants with CPP during surgical removal to potentially aid hemostasis and therefore lessen intra-operative bleeding. Gross total surgical resection was accomplished; the patients were hemodynamically stable perioperatively, and the total calculated blood loss was minimal at <20% of the patients' total circulating blood volume. This is the first report of tranexamic acid administration for CPP surgery in children. TXA is an easily administered hemostatic agent and may merit further study as an agent to help reduce intra-operative blood loss in this vulnerable population.
脉络丛乳头状瘤（CPP）是一种婴儿期的高血管性肿瘤。减少失血是成功手术切除CPP的关键。氨甲环酸（TXA）在减少婴儿颅面手术出血方面有效。本报告证明了TXA在减少婴儿血管肿瘤切除术中失血的潜在效用。我们在两名患有CPP的婴儿手术切除过程中给予氨甲环酸，以潜在地帮助止血，从而减少术中出血。实现了肿瘤全切；患者围手术期血流动力学稳定，计算出的总失血量极少，<患者总循环血量的20%。这是关于儿童CPP手术中使用氨甲环酸的首例报告。TXA是一种易于给药的止血剂，作为帮助减少这一脆弱人群术中失血的药物，可能值得进一步研究。
