创伤后应激障碍中，海马体大小差异是否由睡眠病理介导？
Are hippocampal size differences in posttraumatic stress disorder mediated by sleep pathology?
作者信息
Mohlenhoff Brian S, Chao Linda L, Buckley Shannon T, Weiner Michael W, Neylan Thomas C
机构信息
Department of Psychiatry, University of California, San Francisco, San Francisco, CA, USA; Center for Imaging of Neurodegenerative Diseases, Department of Veterans Affairs Medical Center, San Francisco, CA, USA; Mental Health Service, Department of Veterans Affairs Medical Center, San Francisco, CA, USA.
Department of Psychiatry, University of California, San Francisco, San Francisco, CA, USA; Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA; Center for Imaging of Neurodegenerative Diseases, Department of Veterans Affairs Medical Center, San Francisco, CA, USA.
出版信息
Alzheimers Dement. 2014 Jun;10(3 Suppl):S146-54. doi: 10.1016/j.jalz.2014.04.016.
Posttraumatic stress disorder (PTSD) is associated with smaller volumes of the hippocampus, as has been demonstrated by meta-analyses. Proposed mechanistic relationships are reviewed briefly, including the hypothesis that sleep disturbances mediate the effects of PTSD on hippocampal volume. Evidence for this includes findings that insomnia and restricted sleep are associated with changes in hippocampal cell regulation and impairments in cognition. We present results of a new study of 187 subjects in whom neither PTSD nor poor sleep was associated with lower hippocampal volume. We outline a broad research agenda centered on the hypothesis that sleep changes mediate the relationship between PTSD and hippocampal volume.
创伤后应激障碍（PTSD）与海马体体积较小有关，这已被荟萃分析所证实。本文简要回顾了相关的机制关系，包括睡眠障碍介导PTSD对海马体体积影响的假说。支持这一假说的证据包括：失眠和睡眠受限与海马体细胞调节变化及认知障碍有关。我们公布了一项针对187名受试者的新研究结果，在这些受试者中，PTSD和睡眠不佳均与海马体体积较小无关。我们概述了一项广泛的研究议程，其核心假说是睡眠变化介导了PTSD与海马体体积之间的关系。
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