Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, Germany.
Sleep. 2013 May 1;36(5):731-7. doi: 10.5665/sleep.2638.
Sleep has been demonstrated to significantly modulate brain plasticity and the manifestation of mental disorders. However, previous studies on the effect of disrupted sleep on brain structure have reported inconsistent results. The goal of the current study was to investigate brain morphometry in a well-characterized large sample of patients with primary insomnia (PI) in comparison with good sleeper controls.
Automated parcellation and pattern recognition approaches were supplemented by voxelwise analyses of gray and white matter volumes to analyze magnetic resonance images. All analyses included age, sex, and total intracranial volume as covariates.
Department of Psychiatry and Psychotherapy of the University of Freiburg Medical Center.
There were 28 patients with PI (10 males; 18 females; age 43.7 ± 14.2 y) and 38 healthy, good sleepers (17 males; 21 females; age 39.6 ± 8.9 y).
N/A.
No significant between-group differences were observed in any of the investigated brain morphometry variables.
Altered brain function in insomnia does not appear to have a substantial effect on brain morphometry on a macroscopic level.
睡眠已被证明能显著调节大脑可塑性和精神障碍的表现。然而，先前关于睡眠中断对大脑结构影响的研究结果并不一致。本研究的目的是在一个特征良好的原发性失眠（PI）患者大样本中，与睡眠良好的对照组进行对比，研究脑形态计量学。
采用自动分割和模式识别方法，并结合灰质和白质体积的体素分析，分析磁共振图像。所有分析均包括年龄、性别和总颅内体积作为协变量。
弗赖堡大学医学中心精神病学和心理治疗系。
共有 28 名 PI 患者（10 名男性；18 名女性；年龄 43.7 ± 14.2 岁）和 38 名健康、睡眠良好的对照组（17 名男性；21 名女性；年龄 39.6 ± 8.9 岁）。
无。
在所研究的脑形态计量学变量中，两组之间均无显著差异。
失眠症患者的大脑功能改变似乎对宏观水平的大脑形态计量学没有实质性影响。
