Wang Ling, El Azazi Mildred, Eklund Anders, Burstedt Marie, Wachtmeister Lillemor
Department of Ophthalmology, Ruijin Hospital, Medicine School of Shanghai, Jiaotong University, Shanghai, China; Department of Clinical Sciences, Ophthalmology, Umeå University, Umeå, Sweden.
Acta Ophthalmol. 2015 Mar;93(2):146-53. doi: 10.1111/aos.12456. Epub 2014 Jun 12.
Developmental characteristics of the neuronal adaptive system of the retina, focusing on background light (BGL) adaptation and readaptation functions, were studied by measuring the oscillatory response (SOP) of the electroretinogram (ERG).
Digitally filtered and conventional ERGs were simultaneously recorded. Rats aged 15 and 17 days were studied during exposure to BGLs of two mesopic intensities and during readaptation to dark.
Results were compared to adult rats. In 'low mesopic' BGL SOP instantly dropped significantly to about half of its dark-adapted (DA) value contrary to mature rats, in which the SOP significantly increased. In 'high mesopic' BGL SOP decreased to about 20% and 30% of DA values in immature and adult rats, respectively. The process of recovery of SOP in darkness lacked the transient enhancement immediately as BGL was turned off, characteristic of adult rats. There were no major age differences in adaptive behaviour of a-wave. In young rats, recovery of b-wave was relatively slower.
Properties of BGL adaptation and readaptation functions of the neuronal adaptive system in baby retina differed compared to the adult one by being less forceful and more restrained. Handling of mesopic illumination and recovery in the dark was immature. Development of these functions of the neuronal adaptive system progresses postnatally and lags behind that of the photoreceptor response and seems to be delayed also compared to that of the bipolar response.
通过测量视网膜电图（ERG）的振荡反应（SOP），研究视网膜神经元自适应系统的发育特征，重点关注背景光（BGL）适应和重新适应功能。
同时记录数字滤波和传统的ERG。对15日龄和17日龄的大鼠在暴露于两种中亮度的BGL期间以及重新适应黑暗期间进行研究。
将结果与成年大鼠进行比较。在“低中亮度”BGL下，SOP立即显著下降至其暗适应（DA）值的约一半，这与成年大鼠相反，成年大鼠的SOP显著增加。在“高中亮度”BGL下，未成熟大鼠和成年大鼠的SOP分别降至DA值的约20%和30%。在黑暗中SOP的恢复过程缺乏成年大鼠特有的在BGL关闭后立即出现的短暂增强。a波的适应行为没有明显的年龄差异。在幼鼠中，b波的恢复相对较慢。
与成年视网膜相比，幼鼠视网膜神经元自适应系统的BGL适应和重新适应功能的特性较弱且受到更多限制。对中亮度照明的处理和在黑暗中的恢复尚不成熟。神经元自适应系统这些功能的发育在出生后进行，落后于光感受器反应的发育，并且似乎也比双极细胞反应的发育延迟。
