el Azazi M, Wachtmeister L
Department of Ophthalmology, Karolinska Institute, Huddinge University Hospital, Sweden.
Acta Ophthalmol (Copenh). 1992 Apr;70(2):194-200. doi: 10.1111/j.1755-3768.1992.tb04123.x.
The postnatal development of the oscillatory potentials (OP) of the rat's electroretinogram (ERG) was studied during relatively mesopic adaptational conditions. The behaviour of the OPs induced at an interstimulus interval (ISI) of 30 sec entailed photopic qualities at an individual level, but when summated conformed to a scotopic course of postnatal maturation. An ISI of 1 min elicited OPs with individual scotopic characteristics. The total oscillatory activity culminated at 17 days of age at both ISIs, similar to more scotopically induced oscillations. These results show that relatively mesopic states of adaptation do not promote any earlier appearance of the OPs, and that the immature mesopically induced OPs seem to contain both scotopic and photopic qualities reflecting a postnatal change of balance between these components. Furthermore, photopic mechanisms seem to govern the oscillatory activity in the mature rat retina. We suggest that the differences in relation to adaptational conditions between the immature and mature OPs may reflect the postnatal status of the dopamine and its synthetizing enzyme, tyrosine-hydroxylase.
在相对中间视觉适应条件下，研究了大鼠视网膜电图（ERG）振荡电位（OP）的产后发育。在30秒的刺激间隔（ISI）下诱发的OP行为在个体水平上具有明视觉特性，但汇总后符合暗视觉产后成熟过程。1分钟的ISI诱发具有个体暗视觉特征的OP。在两个ISI下，总振荡活动在17日龄时达到峰值，类似于更多由暗视觉诱发的振荡。这些结果表明，相对中间视觉适应状态不会促进OP更早出现，并且未成熟的中间视觉诱发的OP似乎包含暗视觉和明视觉特性，反映了这些成分之间产后平衡的变化。此外，明视觉机制似乎控制着成熟大鼠视网膜中的振荡活动。我们认为，未成熟和成熟OP在适应条件方面的差异可能反映了多巴胺及其合成酶酪氨酸羟化酶的产后状态。
