喂食后发热。一种古老的氧化磷酸化解偶联剂经重新设计用于治疗非酒精性脂肪性肝病。
Burn after feeding. An old uncoupler of oxidative phosphorylation is redesigned for the treatment of nonalcoholic fatty liver disease.
作者信息
Fromenty B
机构信息
Inserm, U991, université de Rennes 1, 35000 Rennes, France.
出版信息
Clin Res Hepatol Gastroenterol. 2014 Oct;38(5):545-9. doi: 10.1016/j.clinre.2014.04.013. Epub 2014 Jun 9.
Uncoupling of oxidative phosphorylation (OXPHOS) in brown adipose tissue can be used by hibernating animals to produce heat at the expense of their fat mass. In a recent work, Dr Shulman et al. generated a liver-targeted derivative of the prototypical OXPHOS uncoupler 2,4-dinitrophenol that alleviated steatosis, hypertriglyceridemia and insulin resistance in several models of nonalcoholic fatty liver disease and type 2 diabetes.
棕色脂肪组织中氧化磷酸化（OXPHOS）的解偶联可被冬眠动物用来以消耗自身脂肪量为代价产生热量。在最近的一项研究中，舒尔曼博士等人制备了一种靶向肝脏的典型OXPHOS解偶联剂2,4-二硝基苯酚衍生物，该衍生物在几种非酒精性脂肪性肝病和2型糖尿病模型中减轻了脂肪变性、高甘油三酯血症和胰岛素抵抗。
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