上皮细胞黏附分子的表达与肝细胞癌中升高的小胆管反应相关。
Expression of epithelial cell adhesion molecule associated with elevated ductular reactions in hepatocellar carcinoma.
作者信息
Xu Minhui, Qian Guangyang, Xie Feng, Shi Changying, Yan Long, Yu Lihan, Zheng Tao, Wei Lixin, Yang Jiamei
机构信息
Department of General Surgery, the Suzhou Hospital Affiliated to Nanjing Medical University, Suzhou 215001, China; Tumor Immunology and Gene Therapy Center, Eastern Hepatobiliary Surgery Hospital, the Second Military Medical University, Shanghai 200438, China.
Tumor Immunology and Gene Therapy Center, Eastern Hepatobiliary Surgery Hospital, the Second Military Medical University, Shanghai 200438, China; Department of Gastrointestinal surgery, the Third Affiliated Hospital of Soochow University, Changzhou 213003, China.
出版信息
Clin Res Hepatol Gastroenterol. 2014 Dec;38(6):699-705. doi: 10.1016/j.clinre.2014.04.015. Epub 2014 Jun 9.
AIM
To evaluate the prognostic significance of the epithelial cell adhesion molecule (EpCAM) expression in HCC, the relationship between EpCAM with ductular reactions and other clinical features.
METHODS
From 2001 to 2003, 106 HCC patients who underwent curative resection in Eastern Hepatobiliary Hospital were enrolled. The expression of EpCAM in tumoral tissues and ductular reactions in paired non-tumoral tissues was assessed by immunohistochemistry. EpCAM was evaluated with prognosis, ductular reactions and other clinical variables.
RESULTS
HCC expressing high level of EpCAM showed more aggressively than usual progressed HCC. High EpCAM expression was associated with poor overall survival and recurrence free survival. (P=0.0005, 0.0019, respectively). A close association was found between tumoral EpCAM expression and peritumoral ductular reactions. Patients with high level of ductular reactions tended to have higher EpCAM expression than those with low level (P=0.016).
CONCLUSION
HCC stratification by EpCAM may reflect different prognosis. EpCAM expression correlated with ductular reactions may be a result of unregulated activation and differentiation blockage of progenitor cells.
目的
评估上皮细胞黏附分子（EpCAM）表达在肝癌中的预后意义，以及EpCAM与小胆管反应和其他临床特征之间的关系。
方法
选取2001年至2003年在东方肝胆医院接受根治性切除的106例肝癌患者。采用免疫组织化学法评估肿瘤组织中EpCAM的表达以及配对的非肿瘤组织中的小胆管反应。对EpCAM与预后、小胆管反应及其他临床变量进行评估。
结果
高表达EpCAM的肝癌比一般进展性肝癌侵袭性更强。EpCAM高表达与总生存期和无复发生存期较差相关（分别为P = 0.0005，0.0019）。肿瘤EpCAM表达与肿瘤周围小胆管反应密切相关。小胆管反应水平高的患者比小胆管反应水平低的患者EpCAM表达更高（P = 0.016）。
结论
根据EpCAM对肝癌进行分层可能反映不同的预后。EpCAM表达与小胆管反应相关可能是祖细胞异常激活和分化阻滞的结果。
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