Richter V, Rotzsch W
Z Alternsforsch. 1977;32(6):561-5.
Age-dependent modifications of enzyme adaptations in response to a variety of environmental alterations are a biochemical expression of biological ageing. In this paper age-dependent changes of the adaptation of a number of enzymes are described. Experiments from our laboratory indicate that pyruvate kinase is more responsive to starvation and refeeding in young animals. The diminished response of pyruvate kinase in old age is caused by a decreased adaptability of the regulatory isoenzyme PK-L.
酶适应随年龄增长对各种环境变化的改变是生物衰老的一种生化表现。本文描述了多种酶适应的年龄依赖性变化。我们实验室的实验表明，丙酮酸激酶在幼龄动物中对饥饿和再喂养的反应更敏感。老年时丙酮酸激酶反应减弱是由调节性同工酶PK-L的适应性降低所致。
