厌氧诱导大肠杆菌烷基化诱导型aidB基因
Induction of the alkylation-inducible aidB gene of Escherichia coli by anaerobiosis.
作者信息
Volkert M R, Hajec L I, Nguyen D C
机构信息
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester 01655.
出版信息
J Bacteriol. 1989 Feb;171(2):1196-8. doi: 10.1128/jb.171.2.1196-1198.1989.
Abstract
Induction of the adaptive response to alkylation damage results in the expression of four genes arranged in three transcriptional units: the ada-alkB operon and the alkA and aidB genes. Adaptive-response induction requires the ada gene product and occurs when cells are treated with methylating agents. In previous studies we noted that aidB, but not alkA or ada-alkB, was induced in the absence of alkylation damage as cells were grown to stationary phase. In this note we present evidence that aidB is induced by anaerobiosis. Thus, aidB is subject to dual regulation by ada-dependent alkylation induction and ada-independent anaerobic induction.
摘要
对烷基化损伤的适应性反应的诱导导致四个基因的表达，这些基因排列在三个转录单元中：ada-alkB操纵子以及alkA和aidB基因。适应性反应的诱导需要ada基因产物，并且在细胞用甲基化剂处理时发生。在先前的研究中，我们注意到，当细胞生长到稳定期时，在没有烷基化损伤的情况下，aidB会被诱导，而alkA或ada-alkB则不会。在本报告中，我们提供证据表明aidB是由厌氧诱导的。因此，aidB受到ada依赖性烷基化诱导和ada非依赖性厌氧诱导的双重调控。
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1
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J Bacteriol. 1982 May;150(2):984-8. doi: 10.1128/jb.150.2.984-988.1982.
2
Operon fusions in the nitrate reductase operon and study of the control gene nir R in Escherichia coli.大肠杆菌中硝酸盐还原酶操纵子的操纵子融合及调控基因nirR的研究。
Mol Gen Genet. 1981;182(3):477-9. doi: 10.1007/BF00293938.
3
Molecular cloning of a gene which regulates the adaptive response to alkylating agents in Escherichia coli.调控大肠杆菌对烷化剂适应性反应的基因的分子克隆。
Mol Gen Genet. 1983;191(3):466-72. doi: 10.1007/BF00425764.
4
Regulatory mechanisms for induction of synthesis of repair enzymes in response to alkylating agents: ada protein acts as a transcriptional regulator.响应烷基化剂诱导修复酶合成的调控机制：ada蛋白作为转录调节因子发挥作用。
Proc Natl Acad Sci U S A. 1986 Sep;83(17):6297-301. doi: 10.1073/pnas.83.17.6297.
5
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Environ Mol Mutagen. 1988;11(2):241-55. doi: 10.1002/em.2850110210.
6
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Genetics. 1986 Jan;112(1):11-26. doi: 10.1093/genetics/112.1.11.
7
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8
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