影响大肠杆菌对烷化剂适应性反应的ada和adc突变的基因定位。
Genetic mapping of ada and adc mutations affecting the adaptive response of Escherichia coli to alkylating agents.
作者信息
Sedgwick B
出版信息
J Bacteriol. 1982 May;150(2):984-8. doi: 10.1128/jb.150.2.984-988.1982.
Abstract
The adaptive response to alkylating agents is an inducible repair system which protects Escherichia coli against the mutagenicity and toxicity of these agents. Four mutations, ada-3, ada-5, ada-6, and adc-1, which confer differing phenotypes as regards this response, were shown to be cotransducible with gyrA, and were located at 47 min on the E. coli genetic map. A mutation already shown on the map at 47 min as tag (B. J. Bachmann and K. B. Low, Microbiol. Rev. 44:1--56, 1980; Karran et al., J. Mol. Biol. 140:101--127, 1980) is now known to be an ada mutation (G. Evensen and E. Seeberg, personal communication).
摘要
对烷化剂的适应性反应是一种可诱导的修复系统，可保护大肠杆菌免受这些试剂的致突变性和毒性影响。四个突变，ada - 3、ada - 5、ada - 6和adc - 1，在这种反应方面表现出不同的表型，已证明它们与gyrA共转导，并位于大肠杆菌遗传图谱的47分钟处。遗传图谱上已显示在47分钟处的一个突变，标记为tag（B. J. 巴赫曼和K. B. 洛，《微生物学评论》44:1 - 56，1980；卡兰等人，《分子生物学杂志》140:101 - 127，1980），现在已知是一个ada突变（G. 埃文森和E. 西伯格，个人交流）。
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本文引用的文献
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