Balthazart J, Deviche P, Hendrick J C
Laboratoire de Biochimie Générale et Comparée, Belgium; Laboratoire de Radioimmunologie, Université de Liège, Belgium.
Behav Processes. 1980 Dec;5(4):323-38. doi: 10.1016/0376-6357(80)90016-9.
During three independent experiments, we demonstrated that repeated injections of testosterone propionate (TP) induce, after the termination of treatment, a strong inhibition of social displays in intact male domestic ducks. This behavioural inhibition may last for several months and appears relatively specific, as sexual behaviour was generally normal in the previously injected birds. This effect is probably not directly related to the neonatal differentiation of the brain, as it can be induced by injections given when the birds are already several months old. The inhibition of social displays is not paralleled by drastic changes in the plasma levels of pituitary-gonadal hormones (testosterone, follicle stimulating hormone and luteinizing hormone), and thus is not explained by the lack of endogenous testosterone. It is postulated that the behavioural inhibition results from a decreased sensitivity to testosterone of the neural mechanisms involved in the control of displays, and possible mechanisms explaining this decreased sensitivity at the biochemical level are briefly reviewed.
在三项独立实验中，我们证明，在完整的雄性家鸭中，重复注射丙酸睾酮（TP）在治疗结束后会导致社交行为表现受到强烈抑制。这种行为抑制可能持续数月，且似乎具有相对特异性，因为先前注射过的鸟类的性行为通常是正常的。这种效应可能与大脑的新生儿期分化没有直接关系，因为在鸟类已经几个月大时注射也能诱导出这种效应。社交行为表现的抑制与垂体 - 性腺激素（睾酮、促卵泡激素和促黄体生成素）的血浆水平的剧烈变化并不平行，因此不能用内源性睾酮缺乏来解释。据推测，行为抑制是由于控制行为表现的神经机制对睾酮的敏感性降低所致，本文简要回顾了在生化水平上解释这种敏感性降低的可能机制。
