Zhang Xi, Simons Michael
From the Department of Cell Biology, and Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT.
Arterioscler Thromb Vasc Biol. 2014 Sep;34(9):1831-7. doi: 10.1161/ATVBAHA.114.303217. Epub 2014 Jun 12.
Receptor tyrosine kinases are involved in regulation of key processes in endothelial biology, including proliferation, migration, and angiogenesis. It is now generally accepted that receptor tyrosine kinase signaling occurs intracellularly and on the plasma membrane, although many important details remain to be worked out. Endocytosis and subsequent intracellular trafficking spatiotemporally regulate receptor tyrosine kinase signaling, whereas signaling endosomes provide a platform for the compartmentalization of signaling events. This review summarizes recent advances in our understanding of endothelial receptor tyrosine kinase endocytosis and signaling using vascular endothelial growth factor receptor-2 as a paradigm.
受体酪氨酸激酶参与内皮生物学关键过程的调控，包括增殖、迁移和血管生成。目前普遍认为，受体酪氨酸激酶信号传导发生在细胞内和质膜上，尽管许多重要细节仍有待阐明。内吞作用及随后的细胞内运输在时空上调节受体酪氨酸激酶信号传导，而信号内体为信号事件的分隔提供了一个平台。本综述以血管内皮生长因子受体-2为范例，总结了我们对内皮受体酪氨酸激酶内吞作用和信号传导理解的最新进展。
