Ren Wei, Pan Huixuan, Wang Peng, Lan Lei, Chen Wei, Wang Yan, Ni Lijun, Peng Li
Department of Nephrology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, Anhui 230001, P.R. China.
Exp Ther Med. 2014 Jun;7(6):1713-1717. doi: 10.3892/etm.2014.1646. Epub 2014 Mar 28.
The present study aimed to investigate the pathogen distribution and drug resistance of lung infections in hemodialysis to guide clinical empirical pharmacy. The clinical data of 116 hemodialysis patients with pulmonary infection were analyzed. The majority of the 82 pathogens isolated from the sputa of patients were Gram-negative bacteria (accounting for 71.95%). The results of the drug sensitivity test suggested that Gram-negative bacilli had low resistance rates to piperacillin and tazobactam, imipenem and amikacin, while Gram-positive cocci had a low resistance rate to vancomycin. All resistance rates of the pathogens to other common antimicrobials were >50%. The pathogens resulting in lung infections in hemodialysis patients were mainly Gram-negative bacteria and were significantly resistant to various antibacterials. Results of the this study demonstrate that pathological examination should be performed as early as possible and effective antimicrobial agents should be chosen according to drug sensitivity test results.
本研究旨在调查血液透析患者肺部感染的病原菌分布及耐药情况，以指导临床经验用药。分析了116例血液透析合并肺部感染患者的临床资料。从患者痰液中分离出的82株病原菌中，大部分为革兰阴性菌（占71.95%）。药敏试验结果显示，革兰阴性杆菌对哌拉西林和他唑巴坦、亚胺培南和阿米卡星的耐药率较低，而革兰阳性球菌对万古霉素的耐药率较低。病原菌对其他常用抗菌药物的耐药率均>50%。导致血液透析患者肺部感染的病原菌主要为革兰阴性菌，且对多种抗菌药物耐药性显著。本研究结果表明，应尽早进行病原学检查，并根据药敏试验结果选择有效的抗菌药物。
