Cremona Catherine A, Sarangi Prabha, Zhao Xiaolan
Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
Programs in Biochemistry, Cell, and Molecular Biology, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA.
Biomolecules. 2012 Sep 4;2(3):376-388. doi: 10.3390/biom2030376. eCollection 2012 Sep.
The cellular response to DNA damage involves multiple pathways that work together to promote survival in the face of increased genotoxic lesions. Proteins in these pathways are often posttranslationally modified, either by small groups such as phosphate, or by protein modifiers such as ubiquitin or SUMO. The recent discovery of many more SUMO substrates that are modified at higher levels in damage conditions adds weight to the accumulated evidence suggesting that sumoylation plays an important functional role in the DNA damage response. Here we discuss the significance of DNA damage-induced sumoylation, the effects of sumoylation on repair proteins, sumoylation dynamics, and crosstalk with other posttranslational modifications in the DNA damage response.
细胞对DNA损伤的反应涉及多种途径，这些途径共同作用以促进细胞在面对增加的基因毒性损伤时存活。这些途径中的蛋白质通常会发生翻译后修饰，修饰基团可以是诸如磷酸基团之类的小分子，也可以是诸如泛素或类泛素化修饰小蛋白（SUMO）之类的蛋白质修饰剂。最近发现了更多在损伤条件下被更高水平修饰的SUMO底物，这进一步证明了积累的证据，表明类泛素化修饰小蛋白化在DNA损伤反应中发挥重要的功能作用。在这里，我们讨论DNA损伤诱导的类泛素化修饰小蛋白化的意义、类泛素化修饰小蛋白化对修复蛋白的影响、类泛素化修饰小蛋白化动力学以及在DNA损伤反应中与其他翻译后修饰的相互作用。
