中枢性性早熟女孩长期接受促性腺激素释放激素激动剂治疗后的初潮年龄及接近成人身高情况。
Age of menarche and near adult height after long-term gonadotropin-releasing hormone agonist treatment in girls with central precocious puberty.
作者信息
Baek Joon-Woo, Nam Hyo-Kyoung, Jin Dahee, Oh Yeon Joung, Rhie Young-Jun, Lee Kee-Hyoung
机构信息
Department of Pediatrics, Korea University College of Medicine, Seoul, Korea.
Department of Pediatrics, Hallym University Kangnam Sacred Heart Hospital, Seoul, Korea.
出版信息
Ann Pediatr Endocrinol Metab. 2014 Mar;19(1):27-31. doi: 10.6065/apem.2014.19.1.27. Epub 2014 Mar 31.
Abstract
PURPOSE
Gonadotropin-releasing hormone agonist (GnRHa) is known for improving final adult height in patients with central precocious puberty (CPP). This study aimed to investigate the age of menarche and near adult height in girls with CPP who had been treated with GnRHa.
METHODS
In this retrospective study, we reviewed the medical records of 71 Korean girls with CPP who had started menarche or reached over 13 years of bone age after long-term GnRHa treatment. We estimated near adult height using the Bayley-Pinneau method and identified the age of menarche in girls with CPP.
RESULTS
Mean chronological and bone age at menarche were 11.9±0.7 and 12.8±0.4 years, respectively. The period between menarche and the end of treatment was 14.0±5.6 months. Posttreatment near adult height was 163.8±4.7 cm, which was significantly greater than pretreatment predicted adult height (158.7±4.1 cm).
CONCLUSION
GnRHa treatment in girls with CPP could improve final adult height and made the age of menarche close to that of the general population.
摘要
目的
促性腺激素释放激素激动剂（GnRHa）因可改善中枢性性早熟（CPP）患者的最终成年身高而闻名。本研究旨在调查接受GnRHa治疗的CPP女童的初潮年龄和接近成年时的身高。
方法
在这项回顾性研究中，我们回顾了71例接受长期GnRHa治疗后已开始月经初潮或骨龄超过13岁的韩国CPP女童的病历。我们使用贝利-皮诺方法估计接近成年时的身高，并确定CPP女童的初潮年龄。
结果
初潮时的平均实际年龄和骨龄分别为11.9±0.7岁和12.8±0.4岁。初潮至治疗结束的时间为14.0±5.6个月。治疗后接近成年时的身高为163.8±4.7厘米，显著高于治疗前预测的成年身高（158.7±4.1厘米）。
结论
对CPP女童进行GnRHa治疗可提高最终成年身高，并使初潮年龄接近一般人群。
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