Sadeh M, Martinovits G, Goldhammer Y
Department of Neurology, Chaim Sheba Medical Center, Tel Hashomer, Israel.
Neurology. 1989 Feb;39(2 Pt 1):282-3. doi: 10.1212/wnl.39.2.282.
We describe a family in which the father had neurofibromatosis-1 and the mother neurofibromatosis-2. Their son presented at the age of 8 years with bilateral acoustic neuromas, meningioma, and numerous neurofibromas. We believe that the occurrence of the genes responsible for both forms of neurofibromatosis in the same patient had a synergistic effect on the early rapid growth of neurofibromatoses 1 and 2 neoplasms.
我们描述了一个家庭，其中父亲患有神经纤维瘤病1型，母亲患有神经纤维瘤病2型。他们的儿子在8岁时出现双侧听神经瘤、脑膜瘤和众多神经纤维瘤。我们认为，同一患者体内负责这两种神经纤维瘤病的基因同时出现，对神经纤维瘤病1型和2型肿瘤的早期快速生长产生了协同作用。
