云芝多糖K联合丝裂霉素C治疗及其对免疫反应的影响。
Treatment with Krestin combined with mitomycin C, and effect on immune response.
作者信息
Fujii T, Sugita N, Kobayashi Y, Saito K, Iijima H, Matsunaga K, Ando T, Oguchi Y, Morita I, Yoshikumi C
机构信息
Biomedical Research Laboratories, Kureha Chemical Industrie Co., Ltd., Tokyo, Japan.
出版信息
Oncology. 1989;46(1):49-53. doi: 10.1159/000226680.
The combination effects of Krestin (PSK) and mitomycin C (MMC) were examined in experimental tumor models. PSK was administered either orally or intraperitoneally. Delayed-type footpad reaction and antibody formation against sheep erythrocytes were measured in hosts of which immune functions were depressed by tumor burden. Results of the experiment indicated that the simultaneous administration of PSK and MMC significantly increased the survival rate of tumor-bearing mice and restored more effectively their immune functions compared to those of nontreated tumor-bearing controls or tumor-bearing hosts treated with a single agent.
在实验性肿瘤模型中检测了云芝多糖K（PSK）和丝裂霉素C（MMC）的联合效应。PSK通过口服或腹腔注射给药。在免疫功能因肿瘤负荷而受到抑制的宿主中，测量了迟发型足垫反应和针对绵羊红细胞的抗体形成。实验结果表明，与未治疗的荷瘤对照或接受单一药物治疗的荷瘤宿主相比，同时给予PSK和MMC可显著提高荷瘤小鼠的存活率，并更有效地恢复其免疫功能。
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