University of the Witwatersrand Medical School, South Africa.
Int J Psychiatry Clin Pract. 2000;4(4):275-80. doi: 10.1080/13651500050517821.
A clear genetic influence in suicide has been established. In addition, both the serotonergic and noradrenergic systems appear to have a role in suicide, mood disorders and alcoholism. This paper reviews some of the genes that may possibly be involved in suicide and their link to major depression and alcoholism. The genes that are reviewed act on various enzymes within the serotonergic and catecholaminergic systems. With further study, these entities may form a spectrum along the same disease process associated with variable expressivity of the responsible genes.
自杀行为存在明显的遗传影响。此外，5-羟色胺能和去甲肾上腺素能系统似乎都与自杀、心境障碍和酗酒有关。本文综述了一些可能与自杀有关的基因，以及它们与重性抑郁症和酗酒的关系。所综述的基因作用于 5-羟色胺能和儿茶酚胺能系统中的各种酶。进一步的研究可能会发现，这些实体沿着与相关基因表达可变的相同疾病过程形成一个谱。
