Kawai Tatsuo, Leventhal Joseph, Madsen Joren C, Strober Samuel, Turka Laurence A, Wood Kathryn J
1 Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA. 2 Department of Medicine, Northwestern University School of Medicine, Chicago, IL. 3 Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA. 4 Department of Medicine, Stanford University School of Medicine, Palo Alto, CA. 5 Immune Tolerance Network, Massachusetts General Hospital, Harvard Medical School, Boston, MA. 6 Nuffield Department of Surgical Sciences, Oxford University, Oxford, United Kingdom. 7 Address correspondence to: Laurence A. Turka, M.D., Transplantation Biology Research Center, Department of Surgery, Massachusetts General Hospital, 149 13th St, Room 5101, Boston, MA 02129.
Transplantation. 2014 Jul 27;98(2):117-21. doi: 10.1097/TP.0000000000000260.
Recently, The Transplantation Society convened a workshop to address the question, "What do we need to have in place to make tolerance induction protocols a 'standard of care' for organ transplant recipients over the next decade?" In a productive 2-day meeting, there was wide-ranging discussion on a broad series of topics, resulting in five consensus recommendations as follows: (1) establish a registry of results for patients enrolled in tolerance trials; (2) establish standardized protocols for sample collection and storage; (3) establish standardized biomarkers and assays; (4) include children 12 years and older in protocols that have been validated in adults; and (5) establish a task force to engage third-party payers in discussions of how to fund tolerance trials. Future planned workshops will focus on progress in implementing these recommendations and identifying other steps that the community needs to take.
最近，移植学会召开了一次研讨会，以探讨“为使耐受性诱导方案在未来十年成为器官移植受者的‘护理标准’，我们需要具备哪些条件？” 在为期两天卓有成效的会议中，就一系列广泛的主题进行了广泛讨论，形成了以下五项共识建议：（1）为参与耐受性试验的患者建立结果登记册；（2）建立样本采集和储存的标准化方案；（3）建立标准化的生物标志物和检测方法；（4）在已在成人中得到验证的方案中纳入12岁及以上的儿童；（5）成立一个特别工作组，促使第三方支付方参与关于如何为耐受性试验提供资金的讨论。未来计划召开的研讨会将聚焦于实施这些建议的进展情况，并确定该领域需要采取的其他措施。
