Addiction Unit, City General Hospital, Stoke-on-Trent.
Int J Psychiatry Clin Pract. 1999;3(3):217-9. doi: 10.3109/13651509909022738.
There is growing evidence for the validity of the diagnosis of Attention Deficit Hyperkinetic Disorder (ADHD) in adults, as well as evidence that conduct disorder in adolescents and dissocial personality disorder in adult life are linked to ADHD in childhood. Methylphenidate is an effective treatment of ADHD in adolescents and young adults and it is possible that dissocial personality disorder will respond to methylphenidate. There is no evidence that methylphenidate reduces symptoms of conduct disorder in adolescents or of dissocial personality disorder in young adults, because no studies have evaluated methylphenidate in these conditions. We recorded a dramatic improvement in symptoms, predominantly of conduct disorder, in an adolescent with a previous history of ADHD. Trials of methylphenidate are required in adolescents with conduct disorder and young people with dissocial personality disorder, when there is a past history of probable ADHD.
越来越多的证据表明,成人注意缺陷多动障碍(ADHD)的诊断是有效的,此外还有证据表明,青少年的品行障碍和成年期的反社会人格障碍与儿童时期的 ADHD 有关。哌醋甲酯是青少年和年轻成人 ADHD 的有效治疗药物,反社会人格障碍也可能对哌醋甲酯有反应。没有证据表明哌醋甲酯能减轻青少年的品行障碍或年轻成人的反社会人格障碍的症状,因为没有研究评估哌醋甲酯在这些情况下的疗效。我们记录到一名有 ADHD 既往病史的青少年的症状,主要是品行障碍,有明显改善。当有 ADHD 可能的既往病史时,需要在有品行障碍的青少年和有反社会人格障碍的年轻人中进行哌醋甲酯的试验。