Department of Psychiatry and Neurosciences, Hiroshima University School of Medicine.
Int J Psychiatry Clin Pract. 2000;4(3):241-3. doi: 10.1080/13651500050518154.
Tardive extrapyramidal symptoms (EPS) induced by neuroleptic treatment, and particularly EPS which persist after withdrawal of the drugs, are clinically serious problems. We describe a patient with four types of tardive and persistent EPS such as dystonia, dyskinesia, choreatic movement and myoclonus, induced by haloperidol. These EPS were remarkably inhibited by 3 mg/day risperidone. This is the first published case demonstrating simultaneous development of these four types of tardive EPS induced by a neuroleptic and then reduced by low-dose risperidone treatment. ( Int J Psych Clin Pract 2000; 4: 241 - 243).
抗精神病药物治疗引起的迟发性锥体外系症状（EPS），尤其是药物撤药后持续存在的 EPS，是临床上的严重问题。我们描述了一例由氟哌啶醇引起的四种迟发性和持续性 EPS，如肌张力障碍、运动障碍、舞蹈症和肌阵挛。这些 EPS 明显被 3 毫克/天利培酮抑制。这是首例报道的由抗精神病药物引起的这四种迟发性 EPS 同时发生，然后用低剂量利培酮治疗减少的病例。（Int J Psych Clin Pract 2000; 4: 241-243）。
