Jacquot Julien, Bagheri Haleh, Montastruc Jean-Louis
Therapie. 2014 May-Jun;69(3):259-61. doi: 10.2515/therapie/2014036. Epub 2014 Jun 16.
In August 2012, general practitioners of Haute- Garonne received a letter from Health insurance system, informing that prescriptions could be endorsed by "not substituable" after reporting an adverse drug reactions (ADR). Compared to an equivalent period before this letter, we observed an increase of ADRs reports for generics, mainly concerning gastrointestinal ADR and lack of efficacy.
2012年8月，上加龙省的全科医生收到了来自医疗保险系统的一封信，通知称在报告药物不良反应（ADR）后，处方可以标注为“不可替换”。与收到这封信之前的同期相比，我们观察到仿制药的ADR报告有所增加，主要涉及胃肠道ADR和疗效不佳。
