通过联萘酚衍生的路易斯酸催化对二氢喹诺酮进行对映选择性一锅法合成。
Enantioselective one-pot synthesis of dihydroquinolones via BINOL-derived Lewis acid catalysis.
作者信息
Knipe Peter C, Smith Martin D
机构信息
Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK.
出版信息
Org Biomol Chem. 2014 Jul 28;12(28):5094-7. doi: 10.1039/c4ob00627e.
PMID:24927823
Abstract
A high-yielding and diastereoselective route to biologically significant 2-aryl- and 2-alkyl-3-amido dihydroquinolones has been developed in up to 90 : 10 e.r. by employing a novel Lewis acidic BINOL-derived copper(ii) catalyst.
摘要
通过使用一种新型的路易斯酸性联萘酚衍生的铜（II）催化剂，已经开发出了一条高产率且具有非对映选择性的路线，用于合成具有生物学意义的2-芳基和2-烷基-3-氨基二氢喹诺酮，其对映体比例高达90:10。
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