Kamal K A, Fata J S, Kilroy S, Skelly R R, Ansari A A
Department of Immunology, U.S. Naval Medical Research Unit #3, Cairo, Egypt.
Ann Clin Lab Sci. 1989 Jan-Feb;19(1):56-64.
Bone marrow (BM) cells from BALB/c mice infected with mixed-sex Schistosoma mansoni cercariae were assessed for their capacity to form in vitro colony forming units of erythroid (CFU-e) and granulocyte/macrophage (CFU-c) cells. At four weeks after infection, substantial BM commitment to granulopoiesis was noted by an increase in CFU-c, with no changes in CFU-e. Elevated marrow granulopoietic activity, although to a lesser extent, was also observed five weeks after either male or female cercarial infection. Preferential differentiation of precursor cells into eosinophilic and/or neutrophilic lineages was observed at weeks four and six post bisexual cercarial infection. After eight weeks of mixed infection, there was a marked suppression of CFU-e formation as compared with uninfected or single sex cercariae-infected mice. These results demonstrate that S. mansoni infection appears to influence either the differentiation capacity or the levels of BM cells at the progenitor cell level, and that maturation of worms and/or oviposition may contribute to changes in the CFU-e and CFU-c cell differentiation.
对感染了混合性别的曼氏血吸虫尾蚴的BALB/c小鼠的骨髓（BM）细胞进行评估，以检测其形成红系集落形成单位（CFU-e）和粒细胞/巨噬细胞集落形成单位（CFU-c）的能力。感染后四周，CFU-c增加表明骨髓大量向粒细胞生成方向分化，而CFU-e没有变化。在雄性或雌性尾蚴感染五周后，也观察到骨髓粒细胞生成活性升高，不过程度较轻。在双性尾蚴感染后的第四周和第六周，观察到前体细胞优先分化为嗜酸性和/或中性粒细胞谱系。混合感染八周后，与未感染或单性尾蚴感染的小鼠相比，CFU-e的形成受到明显抑制。这些结果表明，曼氏血吸虫感染似乎在祖细胞水平影响骨髓细胞的分化能力或水平，并且蠕虫的成熟和/或产卵可能导致CFU-e和CFU-c细胞分化的变化。
