Rubinstein Mark L, Rait Michelle A, Prochaska Judith J
Division of Adolescent Medicine at the University of California, San Francisco, San Francisco, CA, USA.
Stanford Prevention Research Center at Stanford University, Stanford, CA, USA.
Drug Alcohol Depend. 2014 Aug 1;141:159-62. doi: 10.1016/j.drugalcdep.2014.05.015. Epub 2014 Jun 2.
Marijuana and tobacco are the substances used most commonly by adolescents and co-occurring use is common. Use of one substance may potentiate the addictive properties of the other. The current study examined the severity of nicotine addiction among teen smokers as a function of co-occurring marijuana use.
Participants were 165 adolescents (13-17 years old) who reported smoking at least 1 cigarette per day (CPD) in the past 30 days. General linear models examined the association of marijuana use with multiple measures of nicotine addiction including the Modified Fagerström Tolerance Questionnaire (mFTQ), Hooked on Nicotine Checklist (HONC), ICD-10, and the Nicotine Dependence Syndrome Scale (NDSS).
The adolescent sample (mean age=16.1 years, SD=0.95) averaged 3.0 CPD (SD=3.0) for 1.98 years (SD=1.5). Most (79.5%) also smoked marijuana in the past 30 days. In models controlling for age, daily smoking status, and years of tobacco smoking, frequency of marijuana use accounted for 25-44% of the variance for all four measures of adolescent nicotine dependence.
Marijuana use was associated with greater reported nicotine addiction among adolescent smokers. The findings suggest a role of marijuana in potentiating nicotine addiction and underscore the need for treatments that address both smoked substances.
大麻和烟草是青少年最常使用的物质，同时使用这两种物质的情况很常见。使用一种物质可能会增强另一种物质的成瘾性。本研究调查了青少年吸烟者中尼古丁成瘾的严重程度与同时使用大麻之间的关系。
参与者为165名青少年（13 - 17岁），他们报告在过去30天内每天至少吸1支香烟（CPD）。通用线性模型研究了大麻使用与尼古丁成瘾的多种测量指标之间的关联，这些指标包括改良的法格斯特罗姆耐受问卷（mFTQ）、尼古丁上瘾清单（HONC）、国际疾病分类第10版（ICD - 10）和尼古丁依赖综合征量表（NDSS）。
青少年样本（平均年龄 = 16.1岁，标准差 = 0.95）平均每天吸3.0支香烟（标准差 = 3.0），吸烟时间为1.98年（标准差 = 1.5）。大多数人（79.5%）在过去30天内也吸食过大麻。在控制了年龄、每日吸烟状况和吸烟年限的模型中，大麻使用频率占青少年尼古丁依赖所有四项测量指标方差的25% - 44%。
在青少年吸烟者中，使用大麻与报告的尼古丁成瘾程度较高有关。研究结果表明大麻在增强尼古丁成瘾方面起到了作用，并强调了针对这两种吸食物质进行治疗的必要性。
