人重组干扰素（α-2-精氨酸，γ）与细胞毒性药物对人黑色素瘤和肾癌细胞系集落形成的联合作用。

Combination effects of human recombinant interferon (alpha-2-arg, gamma) and cytotoxic agents on colony formation of human melanoma and hypernephroma cell lines.

作者信息

Nachbaur D M, Denz H A, Gastl G, Thaler J, Lechleitner M, Braunsteiner H

机构信息

Department of Internal Medicine, University Hospital, Innsbruck, Austria.

出版信息

Cancer Lett. 1989 Jan;44(1):49-53. doi: 10.1016/0304-3835(89)90107-9.

DOI:10.1016/0304-3835(89)90107-9

PMID:2492899

Abstract

Malignant melanoma and hypernephroma show marginal response to chemotherapeutics and interferons when used as single agents. Using a modified soft agar clonogenic assay we investigated the antiproliferative effects of combinations of vinblastine, bleomycin, adriamycin, interferon alpha and gamma. On the hypernephroma cell line combinations of bleomycin and adriamycin with interferon gamma as well as combinations of both interferon types resulted in a synergistic antiproliferative effect. On the melanoma cell line combinations of bleomycin and adriamycin with interferon alpha and combinations of vinblastine with interferon gamma acted in a synergistic manner. All other combinations tested were only additive. Thus far, we could not find any antagonistic effect of interferons and chemotherapeutics.

摘要

恶性黑色素瘤和肾细胞癌在单独使用化疗药物和干扰素时，对其反应有限。我们使用改良的软琼脂克隆形成试验，研究了长春碱、博来霉素、阿霉素、α干扰素和γ干扰素联合使用的抗增殖作用。在肾细胞癌细胞系中，博来霉素和阿霉素与γ干扰素联合使用，以及两种干扰素联合使用，均产生协同抗增殖作用。在黑色素瘤细胞系中，博来霉素和阿霉素与α干扰素联合使用，以及长春碱与γ干扰素联合使用，均有协同作用。所有其他测试的联合使用仅具有相加作用。到目前为止，我们尚未发现干扰素与化疗药物之间存在任何拮抗作用。