Chen Guodi, Tang Jun, Yu Guangwei, Chen Yiping, Wang Liancong, Zhang Yao
Department of Radiation Oncology, The Second Affiliated Hospital, and Cancer Institute, Zhejiang University School of Medicine, Jiefang Road 88, Hangzhou, 310009, People's Republic of China.
Mol Biol Rep. 2014 Sep;41(9):5711-8. doi: 10.1007/s11033-014-3441-x. Epub 2014 Jun 15.
Published data on the association between GSK3B -50C/T (rs334558) and bipolar disorder (BD) are inconclusive. We performed this meta-analysis to evaluate the relationship of this single-nucleotide polymorphism with the susceptibility, and with the age at onset of BD. A literature search was conducted though PubMed, EMBASE, Web of Science and China National Knowledge Infrastructure databases to identify relevant studies up to February 14, 2014. We identified a total of 6 publications including 1,251 cases and 1,804 controls to investigate the effect of GSK3B -50C/T on BD risk, and found no significant association in any genetic models (C vs. T: OR = 1.03, 95 % CI: 0.92-1.15; CC vs. TT+TC: OR = 1.04, 95 % CI: 0.84-1.28; TC+CC vs. TT: OR = 1.16, 95 % CI: 0.97-1.39; and CC vs. TC vs. TT: OR = 1.08, 95 % CI: 0.96-1.22). Subgroup analysis by ethnicity did not change the results. The association between GSK3B -50C/T and age at onset of BD was explored by 6 identified studies with a total of 659 BD type I patients. Similarly, we did not observe significant results in any genetic models (TC+CC vs. TT: SMD = 0.20, 95 % CI: -0.07 to 0.47; CC vs. TT+TC: SMD = 0.11, 95 % CI: -0.10 to 0.32; CC vs. TT: SMD = 0.32, 95 % CI: -0.13 to 0.77). The power analysis and tests for publication bias ensured the reliability of our results. In summary, this meta-analysis suggests that the functional polymorphism -50C/T within the GSK3B gene promoter is unlikely to relate with BD risk. However, more larger and well-designed studies are still needed to yield a conclusive result on the topic.
已发表的关于糖原合成酶激酶3β（GSK3B）-50C/T（rs334558）与双相情感障碍（BD）之间关联的数据尚无定论。我们进行了这项荟萃分析，以评估这种单核苷酸多态性与BD易感性以及发病年龄之间的关系。通过PubMed、EMBASE、科学网和中国知网数据库进行文献检索，以识别截至2014年2月14日的相关研究。我们共确定了6篇出版物，包括1251例病例和1804例对照，以研究GSK3B -50C/T对BD风险的影响，发现在任何遗传模型中均无显著关联（C对T：比值比[OR]=1.03，95%可信区间[CI]：0.92 - 1.15；CC对TT + TC：OR = 1.04，95%CI：0.84 - 1.28；TC + CC对TT：OR = 1.16，95%CI：0.97 - 1.39；以及CC对TC对TT：OR = 1.08，95%CI：0.96 - 1.22）。按种族进行的亚组分析未改变结果。通过6项已确定的研究对总共659例I型BD患者进行了GSK3B -50C/T与BD发病年龄之间关联的探索。同样，我们在任何遗传模型中均未观察到显著结果（TC + CC对TT：标准化均数差[SMD]=0.20，95%CI：-0.07至0.47；CC对TT + TC：SMD = 0.11，95%CI：-0.10至0.32；CC对TT：SMD = 0.32，95%CI：-0.13至0.77）。功效分析和发表偏倚检验确保了我们结果的可靠性。总之，这项荟萃分析表明，GSK3B基因启动子内的功能性多态性-50C/T不太可能与BD风险相关。然而，仍需要更多更大规模且设计良好的研究才能得出关于该主题的确切结果。
