Parashar Pallavi
Department of Diagnostic and Biological Sciences, University of Colorado School of Dental Medicine, Aurora, CO 80045, USA.
J Evid Based Dent Pract. 2014 Jun;14 Suppl:147-53.e1. doi: 10.1016/j.jebdp.2014.04.005. Epub 2014 Apr 5.
Proliferative Verrucous Leukoplakia (PVL) is a multifocal form of progressive leukoplakia with a high rate of malignant transformation that requires early recognition by oral health care providers for proper management.
PVL will frequently appear as an innocuous white lesion or lesions that can easily be overlooked or considered clinically insignificant, yet it has a high rate of malignant transformation. There is limited in-depth knowledge about the pathobiology of PVL. Oral health care providers lack familiarity with this lesion; consequently the intent of this article is to increase awareness of the clinical aspects of PVL.
Case reports, case series and review articles provide a profile of PVL.
It is essential that health care providers performing intraoral examinations are aware that PVL is a distinct and rare form of multifocal oral leukoplakia. PVL commonly affects females above the age of 62. Currently, little is known about its etiopathogenesis. Additionally, no specific treatment modality has proven to be effective in aborting its progression. Because of its high recurrence potential and relentless progression to squamous cell carcinoma, all recurrent and multifocal white lesions of the oral cavity should be viewed with suspicion.
增殖性疣状白斑（PVL）是一种多灶性的进行性白斑，具有较高的恶变率，口腔保健人员需要尽早识别以便进行恰当管理。
PVL常表现为无害的白色损害，容易被忽视或认为临床意义不大，但其恶变率很高。关于PVL的病理生物学的深入了解有限。口腔保健人员对这种损害缺乏认识；因此本文旨在提高对PVL临床特征的认识。
病例报告、病例系列和综述文章提供了PVL的概况。
进行口腔内检查的保健人员必须意识到，PVL是一种独特且罕见的多灶性口腔白斑。PVL通常影响62岁以上的女性。目前，对其病因发病机制知之甚少。此外，尚无特定治疗方式被证明能有效阻止其进展。由于其高复发潜能以及向鳞状细胞癌的持续进展，所有口腔复发性和多灶性白色损害都应予以怀疑。
