Yadav Manju, Mishra Neelima, Sharma Nutan, Chandra Sulekh, Kumar Dinesh
Department of Chemistry, Banasthali University, Banasthali, Rajasthan 304022, India.
Department of Chemistry, Zakir Husain College, University of Delhi, J.L. Nehru Marg, New Delhi 110002, India.
Spectrochim Acta A Mol Biomol Spectrosc. 2014 Nov 11;132:733-42. doi: 10.1016/j.saa.2014.04.185. Epub 2014 May 23.
This study is planned to report the advancement of green microwave approach in the fabrication of a new series of biologically potent (N^X, where X=O/S) donor Schiff bases and their cadmium(II) and tin(II) complexes. The ligands and their metal complexes have been characterized in terms of elemental analysis, molar ionic conductance, magnetic moment and spectral (IR, UV-Vis, NMR ((1)H, (119)Sn), FAB-mass, thermal and XRD) data. The data revealed that the ligands coordinated to the metal center via nitrogen and oxygen/sulfur atoms and form an octahedral arrangement of the ligands around central metal atom. All compounds were evaluated for their in vitro antimicrobial activities against two pathogenic bacteria Bacillus subtilis and Escherichia coli and two fungi Aspergillus niger and Aspergillus flavus by standard disc diffusion method. The discs were stored in an incubator at 37°C. The compounds were dissolved in DMF at 500 and 1000 ppm concentrations for screening biocidal activity. The compounds were dissolved in DMF to get the 100 and 200 ppm concentration of test solutions for screening fungicidal activity. The inhibition zone around each disc was measured (in mm) after 24 h and 96 h for biocidal and fungicidal activities respectively.
本研究旨在报道绿色微波法在制备一系列新型具有生物活性的（N^X，其中X = O/S）供体席夫碱及其镉（II）和锡（II）配合物方面的进展。通过元素分析、摩尔离子电导率、磁矩和光谱（红外、紫外可见、核磁共振（（1）H，（119）Sn）、快原子轰击质谱、热分析和X射线衍射）数据对配体及其金属配合物进行了表征。数据表明，配体通过氮和氧/硫原子与金属中心配位，并在中心金属原子周围形成八面体排列的配体。采用标准纸片扩散法对所有化合物针对两种致病细菌枯草芽孢杆菌和大肠杆菌以及两种真菌黑曲霉和黄曲霉进行了体外抗菌活性评估。纸片置于37°C培养箱中。将化合物分别以500和1000 ppm的浓度溶解于二甲基甲酰胺中以筛选其杀菌活性。将化合物溶解于二甲基甲酰胺中以获得浓度为100和200 ppm的测试溶液用于筛选杀真菌活性。分别在24小时和96小时后测量各纸片周围的抑菌圈（以毫米为单位），用于杀菌和杀真菌活性检测。
