Jex Aaron R, Nejsum Peter, Schwarz Erich M, Hu Li, Young Neil D, Hall Ross S, Korhonen Pasi K, Liao Shengguang, Thamsborg Stig, Xia Jinquan, Xu Pengwei, Wang Shaowei, Scheerlinck Jean-Pierre Y, Hofmann Andreas, Sternberg Paul W, Wang Jun, Gasser Robin B
Faculty of Veterinary Science, The University of Melbourne, Parkville, Victoria, Australia.
University of Copenhagen, Copenhagen, Denmark.
Nat Genet. 2014 Jul;46(7):701-6. doi: 10.1038/ng.3012. Epub 2014 Jun 15.
Trichuris (whipworm) infects 1 billion people worldwide and causes a disease (trichuriasis) that results in major socioeconomic losses in both humans and pigs. Trichuriasis relates to an inflammation of the large intestine manifested in bloody diarrhea, and chronic disease can cause malnourishment and stunting in children. Paradoxically, Trichuris of pigs has shown substantial promise as a treatment for human autoimmune disorders, including inflammatory bowel disease (IBD) and multiple sclerosis. Here we report whole-genome sequencing at ∼140-fold coverage of adult male and female T. suis and ∼80-Mb draft assemblies. We explore stage-, sex- and tissue-specific transcription of mRNAs and small noncoding RNAs.
鞭虫在全球感染了10亿人，并引发一种疾病（鞭虫病），给人类和猪都造成了重大的社会经济损失。鞭虫病与大肠炎症有关，表现为血性腹泻，而慢性病会导致儿童营养不良和发育迟缓。矛盾的是，猪鞭虫作为治疗人类自身免疫性疾病（包括炎症性肠病和多发性硬化症）的方法已显示出巨大潜力。在此，我们报告了成年雄性和雌性猪鞭虫约140倍覆盖度的全基因组测序以及约80兆碱基的草图组装。我们探索了mRNA和小非编码RNA的阶段、性别和组织特异性转录。
