Ran Yong, Shu Hong-Bing, Wang Yan-Yi
Wuhan Institute of Virology, State Key Laboratory of Virology, Chinese Academy of Sciences, Wuhan 430072, China.
College of Life Sciences, Wuhan University, Wuhan 430072, China.
Cytokine Growth Factor Rev. 2014 Dec;25(6):631-9. doi: 10.1016/j.cytogfr.2014.05.003. Epub 2014 May 20.
The recognition of nucleic acids is a general strategy used by the host to detect invading pathogens. Many studies have established that MITA/STING is a central component in the innate immune response to cytosolic DNA and RNA derived from pathogens. MITA can act both as a direct sensor of cyclic dinucleotides (CDNs) and as an adaptor for the recruitment of downstream signaling components. In both roles, MITA is part of signaling cascades that orchestrate innate immune defenses against various pathogens, including viruses, bacteria and parasites. Here, we highlight recent studies that have uncovered the molecular mechanisms of MITA-mediated signal transduction and regulation, and discuss some notable issues that remain elusive.
对核酸的识别是宿主检测入侵病原体的一种常用策略。许多研究已证实，MITA/STING是对病原体来源的胞质DNA和RNA进行先天性免疫应答的核心成分。MITA既可以作为环二核苷酸（CDN）的直接传感器，也可以作为募集下游信号成分的接头分子。在这两种作用中，MITA都是信号级联反应的一部分，这些信号级联反应协调针对包括病毒、细菌和寄生虫在内的各种病原体的先天性免疫防御。在此，我们重点介绍了最近揭示MITA介导的信号转导和调控分子机制的研究，并讨论了一些仍未明确的显著问题。
