非甾体抗炎药相关性胃肠病：发病机制与预防的新进展

NSAID-gastroenteropathy: new aspects of pathogenesis and prevention.

作者信息

Blackler Rory W, Gemici Burcu, Manko Anna, Wallace John L

机构信息

Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

Near East University, Nicosia, Cyprus.

出版信息

Curr Opin Pharmacol. 2014 Dec;19:11-6. doi: 10.1016/j.coph.2014.05.008. Epub 2014 Jun 13.

DOI:10.1016/j.coph.2014.05.008

PMID:24929967

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) remain among the most commonly used medications because of their effectiveness in reducing pain and inflammation. Inhibitors of gastric acid secretion can substantially reduce the damaging effects of NSAIDs in the stomach and duodenum. However, there are no proven effective preventative or curative treatments for NSAID-induced enteropathy. In recent years, substantial progress has been made in better understanding the pathogenesis of NSAID-enteropathy, and in particular the interplay of enteric bacteria, bile and the enterohepatic recirculation of the NSAIDs. Moreover, it is becoming clear that suppression of gastric acid secretion significantly worsens NSAID-enteropathy.

摘要

非甾体抗炎药（NSAIDs）因其在减轻疼痛和炎症方面的有效性，仍然是最常用的药物之一。胃酸分泌抑制剂可以显著降低NSAIDs对胃和十二指肠的损害作用。然而，对于NSAIDs引起的肠病，尚无经证实有效的预防或治疗方法。近年来，在更好地理解NSAIDs肠病的发病机制，特别是肠道细菌、胆汁和NSAIDs肝肠循环之间的相互作用方面取得了重大进展。此外，越来越清楚的是，抑制胃酸分泌会显著加重NSAIDs肠病。